(1S,2S,4R)-1-ethenyl-1-methyl-2,4-bis(1-methylethenyl)cyclohexane
(-)-beta-Elemene
CAS: 515-13-9
Molecular Formula: C15H24
(1S,2S,4R)-1-ethenyl-1-methyl-2,4-bis(1-methylethenyl)cyclohexane - Names and Identifiers
| Name | (-)-beta-Elemene |
| Synonyms | β-Elemen Β-ELEMENE beta-Elemene (-)-beta-Elemene Levo-beta-elemene levo-beta-Elemene (-)-beta-Elemene analytical standard (1S,2S,4R)-(?)-2,4-Diisopropenyl-1-methyl-1-vinylcyclohexane (1S,2S,4R)-1-Ethenyl-1-methyl-2,4-bis(1-methylethenyl)cyclohexane (1S,2S,4R)-1-ethenyl-1-methyl-2,4-bis(1-methylethenyl)cyclohexane C15 H24, Cyclohexan, 1-ethenyl-1-methyl-2,4-bis(1-methylethenyl)- Cyclohexane,1-ethenyl-1-Methyl-2,4-bis(1-Methylethenyl)-, (1S,2S,4R)- Cyclohexane, 1-ethenyl-1-methyl-2,4-bis(1-methylethenyl)-,(1S-(1-alpha,2-beta,4-beta))- |
| CAS | 515-13-9 |
| EINECS | 679-283-3 |
| InChI | InChI=1/C15H24/c1-7-15(6)9-8-13(11(2)3)10-14(15)12(4)5/h7,13-14H,1-2,4,8-10H2,3,5-6H3/t13-,14+,15-/m1/s1 |
| InChIKey | OPFTUNCRGUEPRZ-RBSFLKMASA-N |
(1S,2S,4R)-1-ethenyl-1-methyl-2,4-bis(1-methylethenyl)cyclohexane - Physico-chemical Properties
| Molecular Formula | C15H24 |
| Molar Mass | 204.35 |
| Density | 0.862 |
| Boling Point | 252℃ |
| Flash Point | 98℃ |
| Solubility | DMSO : 50 mg/mL (244.68 mM; Need ultrasonic) |
| Vapor Presure | 0.0313mmHg at 25°C |
| Appearance | Colorless to light yellow (Liquid) |
| BRN | 2207781 |
| Storage Condition | 2-8°C |
| Refractive Index | 1.501 |
| MDL | MFCD00468041 |
(1S,2S,4R)-1-ethenyl-1-methyl-2,4-bis(1-methylethenyl)cyclohexane - Risk and Safety
| Risk Codes | 66 - Repeated exposure may cause skin dryness or cracking |
| WGK Germany | 3 |
| RTECS | GU9660000 |
(1S,2S,4R)-1-ethenyl-1-methyl-2,4-bis(1-methylethenyl)cyclohexane - Reference
| Reference Show more | 1. Hao Min, Lu, Lin, Mao, Chun, Qin, et al. UPLC fingerprint and multi-component content determination of three processed rhizome products of Curcuma wenyujin [J]. Chinese Journal of Traditional Chinese Medicine, 2018, 43(11). 2. [IF = 2.727] Shen Song et al."Spectrum-effect relationship analysis by binary chromographic fingerprint to identify components responsible for the antibacterial activity of the essential oil from Curcumae yuwenjin." Int J Food Prop. 2018;21(1):546-556 3. [IF = 4.35] Yao Ma et al."Volatile Oil Profile of Prickly Ash (Zanthoxylum) Pericarps from Different Locations in China."Foods. 2021 Oct;10(10):2386 4. [IF=5.645] Shenglan Liao et al."Chemical composition of Zanthoxylum schinifolium Siebold & Zucc. essential oil and evaluation of its antifungal activity and potential modes of action on Malassezia restricta."Ind Crop Prod. 2022 Jun;180:114698 |
(1S,2S,4R)-1-ethenyl-1-methyl-2,4-bis(1-methylethenyl)cyclohexane - Reference Information
| Biological activity | β-Elemene ((-)-β-Elemene, Levo-β-Elemene) is a kind of from herbal Curcuma Rhizoma Sesquiterpenes have anti-tumor activity. β-Elemene can inhibit cell proliferation, block cell cycle, and induce apoptosis or autophagy. |
| Cell Line: | T24, 5637, TCCSUP, J82, UM-UC-3, RT4 and SW780 cells T24 and 5637 cells T24 cells |
| Concentration: | 0, 6.25, 12.5, 25, 50, 100, 150 and 200 µg/ml 0, 25, 50 and 75 µg/ml 50 µg/ml |
| Incubation Time: | 24 hours 24 hours 24 hours |
| Result: | Inhibited the proliferation of RT4, SW780, J82, UMUC-3, TCCSUP, 5637 and T24 human bladder cancer cells and SV-HUC-1 human urothelial cells. Induced the percentage of cells in the S-phaseas a dose-dependent manner. Downregulated p-STAT3 and cell cycle-related proteins. |
Last Update：2024-04-09 20:02:46
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