(1S,2S,8R,8AR)-TRIHYDROXYINDOLIZIDINE
swainsonine from locoweed
CAS: 72741-87-8
Molecular Formula: C8H15NO3
(1S,2S,8R,8AR)-TRIHYDROXYINDOLIZIDINE - Names and Identifiers
(1S,2S,8R,8AR)-TRIHYDROXYINDOLIZIDINE - Physico-chemical Properties
| Molecular Formula | C8H15NO3 |
| Molar Mass | 173.21 |
| Density | 1.38±0.1 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 148-149°C |
| Boling Point | 353.3±21.0 °C(Predicted) |
| Specific Rotation(α) | (c, 0.6 in MeOH) -85.1 |
| Flash Point | 209.7°C |
| Solubility | DMSO : 10 mg/mL (57.73 mM; Need ultrasonic and warming);Ethanol : 10 mg/mL (57.73 mM; |
| Vapor Presure | 2.1E-06mmHg at 25°C |
| Appearance | White crystalline powder |
| Color | white to faint yellow |
| BRN | 4175740 |
| pKa | 14.01±0.60(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol or distilled water may be stored at -20°C for up to 3 months. |
| Refractive Index | 1.608 |
| MDL | MFCD00017554 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from oxytropis ochrocephala, mad grass (leguminous astragalus and oxytropis are collectively mad grass), bitter horse beans. |
(1S,2S,8R,8AR)-TRIHYDROXYINDOLIZIDINE - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | 36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | NM2408666 |
| HS Code | 29339900 |
(1S,2S,8R,8AR)-TRIHYDROXYINDOLIZIDINE - Reference Information
| description | in, Colegate was first isolated from a pure toxin of the bitter white beans and was named as the bitter bean, the molecular formula was determined to be C8H15O3N with the chemical name (1S,2R,8R,8AR)-1,2, 8-octahydroindolidine Triol. In recent decades, with the deepening and expansion of its research, it has been found that Momordica can be used as immunomodulators, anti-HIV and diffusion inhibitors, antiviral and cell protective agents and other drugs, it is preliminarily proved that the bitter bean has a certain therapeutic effect on human malignant tumor. |
| preparation | Since the artificial synthesis of Momordica Fallot in 1984, chemical workers in various countries have actively developed the artificial synthesis of Momordica. In view of the molecular structure of the bitter bean is a double heterocyclic ring, and there are four chiral configurations, so many chemical workers design synthetic routes are unsaturated indolicidine ring, bicyclic lactam compounds, cycloenamine compounds and pyrone are key intermediates in the synthesis of mometasone. At the same time, important reaction types such as olefin metathesis reaction, dihydroxylation reaction, Asymmetric oxidation reaction and 1,3-dipolar cycloaddition reaction are also used in the synthesis of Momordica. The synthetic route of octa-indazine triol is as follows: |
| biological activity | Swainsonine is a kind of alkaloids isolated from the genus Astragalus, which is α-mannosidase. Inhibitors, with anti-tumor activity. |
| uses | swamanserin has antiviral, antibacterial, antitumor effects, and is of great significance in the treatment of infectious diseases and immunosuppressive diseases. |
Last Update：2024-04-09 21:11:58
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CAS: 72741-87-8
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CAS: 72741-87-8
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