(1r,2s,4r)-(+)-borneo
(+)-Borneol
CAS: 464-43-7
Molecular Formula: C10H18O
(1r,2s,4r)-(+)-borneo - Names and Identifiers
(1r,2s,4r)-(+)-borneo - Physico-chemical Properties
| Molecular Formula | C10H18O |
| Molar Mass | 154.25 |
| Density | 0.8704 (rough estimate) |
| Melting Point | 206-209 °C (lit.) |
| Boling Point | 237.64°C (rough estimate) |
| Specific Rotation(α) | 36 º (C=5 IN ETOH) |
| Flash Point | 150°F |
| Water Solubility | 0.74g/L(25 ºC) |
| Solubility | Almost insoluble in water |
| Appearance | Colorless hexagonal flake crystal |
| BRN | 2038056 |
| pKa | 15.36±0.60(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.4723 (estimate) |
| MDL | MFCD00066427 |
(1r,2s,4r)-(+)-borneo - Risk and Safety
| Risk Codes | R11 - Highly Flammable R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S16 - Keep away from sources of ignition. S33 - Take precautionary measures against static discharges. S36 - Wear suitable protective clothing. S7/9 - |
| UN IDs | UN 1312 4.1/PG 3 |
| WGK Germany | 3 |
| RTECS | ED7060000 |
| Hazard Class | 4.1 |
| Packing Group | III |
(1r,2s,4r)-(+)-borneo - Reference
| Reference Show more | 1. Li Shunan, Wang Yinquan, Xu mingbrush, etc. Effects of different drying methods on the quality of camphor leaves of borneol [J]. Chinese Journal of Experimental prescriptions 2018(10):72-78. 2. Liu Yang, Yang Yanfang, Hong zonchao, et al. Study on GC fingerprint of volatile oil from Rhizoma curcumae of Guangxi [J]. Journal of Hubei University of Traditional Chinese Medicine, 2018, 000(004):48-51. 3. Li Shunan, Wang Yinquan, Xu Ming brush, etc. Simultaneous determination of dextroborneol, camphor and isoborneol in fresh leaves of Cinnamomum camphora by gas chromatography-mass spectrometry [J]. Journal of Gansu University of Chinese Medicine, 2018, 035(005):P.32-37. 4. Yan Shunan, Wang Yinquan, Ma Lili, et al. Optimization of drying process for balanced dehydration of branches and leaves of Cinnamomum camphora [J]. Journal of Gansu University of Chinese Medicine, 2018. 5. Yang, Zerui, et al. "Mining of candidate genes involved in the biosynthesis of dextrorotatory borneol in Cinnamomum burmannii by transcriptomic analysis on three chemotypes." PeerJ 8 (2020): e9311.https://doi.org/10.7717/peerj.9311 6. [IF=5.81] Li Peng et al."Detection of Vasodilators From Herbal Components by a Transcriptome-Based Functional Gene Module Reference Approach."Front Pharmacol. 2019 Oct;0:1144 7. [IF=3.772] Z.-Y. Zeng et al."Inhibitory effects of essential oils from Asteraceae plant against pathogenic fungi of Panax notoginseng."J Appl Microbiol. 2021 Feb;130(2):592-603 8. [IF=2.984] Zerui Yang et al."Mining of candidate genes involved in the biosynthesis of dextrorotatory borneol in Cinnamomum burmannii by transcriptomic analysis on three chemotypes."Peerj. 2020 Jun;8:e9311 9. [IF=2.984] Zerui Yang et al."Metabolism and transcriptome profiling provides insight into the genes and transcription factors involved in monoterpene biosynthesis of borneol chemotype of Cinnamomum camphora induced by mechanical damage."Peerj. 2021 Jul;9:e11465 10. [IF=3.361] Bin Zan et al."Volatile components in Yinchenzhufu decoction and their pharmacokinetics after oral administration in rats."Rsc Adv. 2022 Jan;12(6):3287-3299 |
(1r,2s,4r)-(+)-borneo - Introduction
There are two epimers of orthosaurus and isoborneol, of which orthosaurus plays a major role. Borneol is a colorless or white translucent flake crystal with a mixed aroma similar to camphor and mint. It is easily soluble in ethanol, ether, petroleum ether, benzene, toluene, acetone, naphthalene, gasoline and other organic solvents, Slightly soluble in water, easy to sublimate.
Last Update：2022-10-16 17:31:06
(1r,2s,4r)-(+)-borneo - Reference Information
| FEMA | 2157 | BORNEOL |
| Introduction | borneol is a plant of the family borneaceae, which is called dryobalans. f. Resin processing products, or borneol tree trunk, branches chopped, by distillation and cooling the crystals, known as "borneol borneol", also known as "plum". The sublimate of leaves of the Asteraceae plant Artemisia balsamifera DC. Is processed and cut, and is called "moxa". At present, turpentine, camphor and so on are commonly used, and are synthesized by chemical methods, called "mechanism borneol". Aralia is mainly produced in Southeast Asia, and introduced in Taiwan. Aralia is mainly produced in Guangdong, Guangxi, Yunnan, Guizhou and other places. The finished borneol should be stored in a cool and closed place. It is used for grinding powder. |
| Chemical constituents | borneol borneol contains d-borneol, and Sesquiterpenes such as humulus, β-elemene and caryophyllene, and oleanolic acid, bezoar acid, Asiatic acid, borneol, coca glycol and other triterpene compounds. Moxa tablets contained L-borneol. Mechanism borneol is racemic mixed borneol. |
| abstract | 1. "New herb": "The Master of the heart and abdomen, rheumatism accumulation, deafness, eyesight, to go to the red eyes. "Compendium of Materia Medica": "Treatment of throat, brain pain, nasal polyp, tooth pain, typhoid tongue out, infantile pox. The fire was dispersed. 3. "Medical forest": "borneol is the main fire, can penetrate the bone heat, cure epilepsy, sputum, throat, tongue swelling, toothache, deafness, nasal breath, eye red, vaccinia virus invagination, insecticidal, hemorrhoids, the birth, sex go and do not keep, also can myogenic pain. However, it is easy to be exhausted. |
| pharmacological effects | borneol and isoborneol, the main components of borneol, have the effect of hypoxia tolerance; Borneol and isoborneol have the effect of sedation; local application of borneol has slight stimulation to the sensory nerve, and has a certain analgesic and mild antiseptic effect; It is rapidly absorbed through the mesentery and can pass through the blood-brain barrier after 5 minutes of administration, and accumulation in the brain for a long time, the amount is quite high, which provides a preliminary experimental basis for the aromatic resuscitation effect of borneol; Higher concentration (0.5%) of Staphylococcus aureus, Streptococcus, pneumonia double ball bacteria, Escherichia coli and some pathogenic skin fungi and so on have inhibitory effect; In late pregnancy mice have induced labor. |
| Clinical Study | a 2-Head Pain borneol patch was placed on a adhesive tape and applied to the ear acupuncture point for treatment, take the master, brain and subcortical (Henan Chinese medicine, 1988,5:23); Dissolve borneol 50g in 75% ethanol and wipe it with cotton ball to treat advanced tumor pain, the rubbing surface should exceed the pain site (Chinese Journal of Nursing, 1991,3:114); External application of borneol cream in the treatment of chronic anal eczema in 62 cases, after 3 courses of treatment (21 days), 59 cases were cured, and the total effective rate was 98.4%. (Jiangsu Traditional Chinese Medicine, 2001,5:30). In addition, there is a single use of borneol or with indigo naturalis, mirabilite made external application (smear) treatment of a variety of surgical infectious inflammation, such as herpes zoster erysipelas, acute mastitis, cellulitis, swelling, lymphangitis, phlebitis, appendiceal abscess. |
| borneol VS Musk | , closed syndrome of Qi-stagnation, orifices-Coma, etc. However, Musk is strong in inducing orifices and borneol is strong, Musk is a product of warm opening, borneol is a cold-opening agent, but it is often necessary to use; Both can reduce swelling and pain, muscle healing sores, external treatment of sore and swelling. However, borneol is rather cold, with good heat-clearing, fire-purging and pain-relieving, good treatment for diseases of mouth, throat and eyes and ears, with heat-clearing and pain-relieving, antiseptic and itching-relieving, bright-looking and falling back, treatment of acne tumefaction and toxin to huoxue Sanjie, swelling and pain for use. Both should be into the pill, powder use, not into the decoction.
Last Update：2024-04-09 20:48:19
Supplier List
Featured ProductsMultiple SpecificationsSpot supply
Product Name: (+)-Borneol Visit Supplier Webpage Request for quotationCAS: 464-43-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Borneol Visit Supplier Webpage Request for quotationCAS: 464-43-7
Tel: 18000738807
Email: 2134411736@qq.com
Mobile: 18000738807
QQ: 2134411736
Wechat: 18000738807
Spot supply
Product Name: (+)-Borneol Visit Supplier Webpage Request for quotationCAS: 464-43-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Featured ProductsMultiple SpecificationsSpot supply
Product Name: (+)-Borneol Visit Supplier Webpage Request for quotationCAS: 464-43-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Borneol Visit Supplier Webpage Request for quotationCAS: 464-43-7
Tel: 18000738807
Email: 2134411736@qq.com
Mobile: 18000738807
QQ: 2134411736
Wechat: 18000738807
Spot supply
Product Name: (+)-Borneol Visit Supplier Webpage Request for quotationCAS: 464-43-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
View History