Molecular Formula | C13H12ClNOS |
Molar Mass | 265.76 |
Density | 1.303±0.06 g/cm3(Predicted) |
Boling Point | 435.4±45.0 °C(Predicted) |
Solubility | DMSO: ≥ 106 mg/mL |
pKa | -1.34±0.13(Predicted) |
Storage Condition | 2-8°C(protect from light) |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.763 ml | 18.814 ml | 37.628 ml |
5 mM | 0.753 ml | 3.763 ml | 7.526 ml |
10 mM | 0.376 ml | 1.881 ml | 3.763 ml |
5 mM | 0.075 ml | 0.376 ml | 0.753 ml |
Application | 2-amino -3-(4-chlorobenzoyl)-4, 5-dimethylthiophene can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development process and chemical generation process. |
preparation | 0. 56g(17 mmol) of sulfur were added to 3g(17 mmol) of 4-chlorobenzoyl-containing acetonitrile, 3. 7 mL(34 mmol)2 -butanone, 5. 9 mL(68 mmol) of morpholine in 30 mL of ethanol. The mixture was heated to 70 °c and reacted 3. After 5 h, cooled to room temperature, poured into 100 mL brine, mixed well, extracted with ethyl acetate (50 mL × 3), combined organic layer, the mixture was washed with 50 mL saturated brine, and the organic layer was collected and dried over anhydrous sodium sulfate. After filtration, the solvent was distilled off under reduced pressure. The residue was subjected to column chromatography eluting with petroleum ether-ethyl acetate (20: 1) to give 4. 3g yellow solid, yield 92. 2%, with HPLC detection purity was 99. 5%. mp434 ~ 436 ℃;MS (m/z):266. 2[M + H] +,288. 2[M + Na] +. |