(2-Bromo-5-fluorophenyl)methanol
2-Bromo-5-fluorobenzyl alcohol
CAS: 202865-66-5
Molecular Formula: C7H6BrFO
(2-Bromo-5-fluorophenyl)methanol - Names and Identifiers
(2-Bromo-5-fluorophenyl)methanol - Physico-chemical Properties
| Molecular Formula | C7H6BrFO |
| Molar Mass | 205.02 |
| Density | 1.658±0.06 g/cm3(Predicted) |
| Melting Point | 91-94 °C |
| Boling Point | 252.5±25.0 °C(Predicted) |
| Flash Point | 96.2°C |
| Water Solubility | Slightly soluble in water. |
| Vapor Presure | 0.0502mmHg at 25°C |
| Appearance | Solid |
| Color | Yellow |
| pKa | 13.67±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| MDL | MFCD00142876 |
(2-Bromo-5-fluorophenyl)methanol - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| Hazard Note | Irritant |
(2-Bromo-5-fluorophenyl)methanol - Reference Information
| use | 2-bromo -5-fluorobenzyl alcohol is an important industrial raw material and is widely used in medicine, pesticides, dyes and other industries. Benzyl alcohol structure has good biological activity and has irreplaceable role of other groups or functional groups in the synthesis of drugs, so it is a hot field in pharmaceutical research. In addition, 2-bromo-5-fluorobenzyl alcohol has special chemical properties and medicinal activity. It is an intermediate for many medicines and pesticides, and its application prospects are very broad [7]. It can also be used as pharmaceutical and pharmaceutical intermediates, hair coloring aids, polymer stabilizers, antioxidants and anti-fog agents for photosensitive materials, etc. |
| synthesis method | preparation method of 2-bromo-5-fluorobenzyl alcohol: methyl 2-bromo-5-fluoro-benzoate (1g,4.292 mmol), NaBH4(0.423g,11.159 mmol) and LiCl(0.474g,11.159 mmol) in THF/EtOH(20 ml/10 ml) was stirred overnight. Add aqueous HCl(10 ml,2N) and stir for about 10 minutes. Then remove the organic solvent under low vacuum. The residue was diluted with water and extracted with ethyl acetate. The organic layer was washed with aqueous NaHCO3(10%), water and brine, then dried (MgSO4) and concentrated to obtain the crude product 2-bromo-5-fluorobenzyl alcohol without further purification. White solid, yield 852mg(96.8%). Figure 2-Bromo-5-fluorobenzyl alcohol synthesis route |
Last Update：2024-04-09 21:04:16
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