Molecular Formula | C6H13NO3 |
Molar Mass | 147.18 |
Density | 1.279 |
Melting Point | 185-186℃ |
Boling Point | 315.4±42.0 °C(Predicted) |
Specific Rotation(α) | (c, 1 in H2O)+23;(c, 1 in 0.1M HCl)+37 |
Solubility | H2O : ≥ 36 mg/mL (244.62 mM) |
Appearance | Yellow powder |
pKa | 14.16±0.60(Predicted) |
Storage Condition | -20℃ |
MDL | MFCD18782654 |
Physical and Chemical Properties | Bioactive Fagomine is a mild glycosidase (glycosidase) inhibitor that Fagomine acts on Amyloglucosidase (A.niger),β-Glucosidase (bovine) and Isomaltase (east) with Ki of 4.8 μM,39 μM and 70 μM respectively. |
Target
Glycosidase
in vitro studies
Fagomine (D-fagomine) is an iminosugar that has been shown to selectively agglutinate Enterobacteriales in vitro. Fagomine selectively agglutinates fimbriated enterobacteria (e.g., E.coli ) and inhibits their adhesion to the intestinal mucosa; the reason for this is probably related to its structural similarity with lectin-binding saccharides (e.g., mannose). Fagomine is capable of altering this effect of high-fat high-sucrose diet (HFHS) on the proportion of Enterobacteriales and E.coli .
In vivo studies
Fagomine (D-fagomine) is a natural iminosugar that counteracts the short-term effects of a high-energy-dense diet on body weight, fasting blood glucose levels and the proportion of gut Enterobacteriales. Compare to the standard group, rats fed high-fat high-sucrose diet (HFHS) with Fagomine (D-fagomine) gain significantly less weight (15.3%) than those fed HFHS (20.9%).