(2R)-3-bromo-2-methylpropan-1-ol

(2R)-3-bromo-2-methylpropan-1-ol - Names and Identifiers

Name	R(-)-3-bromo-2-methyl-1-propanol
Synonyms	(R)-3-BroMo-2-Methylpropan-1-ol (2R)-3-bromo-2-methylpropan-1-ol R(-)-3-bromo-2-methyl-1-propanol (R)-(-)-3-BROMO-2-METHYL-1-PROPANOL (R)-(-)-3-Bromo-2-methyl-1-propanol
CAS	93381-28-3
InChI	InChI=1/C4H9BrO/c1-4(2-5)3-6/h4,6H,2-3H2,1H3/t4-/m0/s1

(2R)-3-bromo-2-methylpropan-1-ol - Physico-chemical Properties

Molecular Formula	C4H9BrO
Molar Mass	153.02
Density	1.461g/mLat 20°C(lit.)
Boling Point	73-74°C9mm Hg(lit.)
Flash Point	187°F
Vapor Presure	0.313mmHg at 25°C
BRN	3600269
Storage Condition	2-8°C
Refractive Index	n20/D 1.4840(lit.)

(2R)-3-bromo-2-methylpropan-1-ol - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
UN IDs	NA 1993 / PGIII
WGK Germany	3
FLUKA BRAND F CODES	9

(2R)-3-bromo-2-methylpropan-1-ol - Introduction

R(-)-3-bromo-2-methyl-1-propanol is a chiral compound with the formula C4H9BrO. Its properties are as follows:

1. appearance: colorless or light yellow liquid.
2. melting point:-2 ℃.
3. Boiling point: 125-126 ℃.
4. relative density: 1.35(20 ℃).
5. Refractive index: 1.470(25 ℃).

The main uses of R(-)-3-bromo-2-methyll-1-propanol include:
1. as a chiral reagent: because its molecule contains chiral carbon atoms, it can be used as a chiral inducer in organic synthesis for the synthesis of chiral compounds.
2. as an intermediate: can be used for the synthesis of sugars, ketones, esters and other organic compounds.
3. for organic synthesis reactions: for example, as a reagent for catalytic asymmetric synthesis reactions, such as asymmetric Michael addition reactions.

The main methods for preparing R(-)-3-bromo-2-methyll-1-propanol are:
1. By the addition of brominated sulfoxide: the sulfoxide and bromoalkane are reacted in the presence of a base to generate R(-)-3-bromo-2-methyl-1-propanol.
2. Alkylation reaction of enol: vinyl chloride and methyl methanol are reacted in the presence of an acid catalyst to generate R(-)-3-bromo-2-methyl-1-propanol.

About safety information:
- R(-)-3-bromo-2-methyll-1-propanol is an organic solvent with certain toxicity. Care should be taken to avoid contact with skin and inhalation of its vapor.
-Wear protective gloves and goggles when using.
-should be sealed when stored, away from fire and oxidant.
-In the process of use, the reasonable operation and handling methods of chemicals should be followed to ensure the safety of individuals and the environment.

Last Update：2024-04-10 22:29:15