Molecular Formula | C17H20N2O2 |
Molar Mass | 284.35 |
Density | 1.161±0.06 g/cm3(Predicted) |
Melting Point | 98 °C |
Boling Point | 492.8±45.0 °C(Predicted) |
Flash Point | 251.8°C |
Water Solubility | 0.2g/L(25 ºC) |
Solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 4.3mg/mL |
Vapor Presure | 1.58E-10mmHg at 25°C |
Appearance | solid |
Color | white |
Maximum wavelength(λmax) | ['254nm(HCl aq.)(lit.)'] |
Merck | 14,9780 |
pKa | pKa 5.3 (Uncertain) |
Storage Condition | 2-8°C |
Refractive Index | 1.586 |
Use | Used as an anticholinergic, mydriatic agent |
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R42/43 - May cause sensitization by inhalation and skin contact. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. R22 - Harmful if swallowed |
Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
WGK Germany | 3 |
RTECS | CY1487860 |
HS Code | 29333990 |
This product is n-ethyl-2-phenyl-n-(4-pyridylmethyl) hydroxypropionamide. Calculated as dried product, the content of C17H20N202 shall not be less than 98.5%.
The melting point of this product (General 0612) is 96~100°C.
take this product, precision weighing, add 0.05mol/L sulfuric acid solution to dissolve and quantitatively dilute to make a solution containing about 25ug per 1 ml, the absorbance was measured at a wavelength of 0401 NM according to ultraviolet-visible spectrophotometry (General Rule 167), and the absorption coefficient was 177.
take about 2.5g of this product, put it in a 25ml measuring flask, add ethanol to dissolve and dilute to the scale, shake well, and determine it according to law (General rule 0621), the optical rotation was -0.1 ° to +0.1 °.
take 0.20g of this product, add 100ml of water to dissolve it, and then measure it according to law (General rule 0631). The pH value should be 6.5-8.0.
take this product l.Og, add ethanol 10ml after dissolution, the solution should be clarified.
take 0.5g of this product, Add 10ml of ethanol to dissolve it, and check it according to law (General rule 0801). Compared with the control solution made of 5ml of standard sodium chloride solution, it should not be more concentrated (0.010%).
take this product, add methylene chloride to dissolve and dilute to make a solution containing about 20mg per 1 ml as a test solution; Take an appropriate amount of precision, respectively diluted with dimethyl methane to contain 0.04mg and 0. A 1 mg solution was used as the Control Solutions (1) and (2). Weigh about 10 mg each of N-(4-pyridylmethyl) ethylamine (impurity I) and tropicamide in a 10ml measuring flask, add dichloromethane to dissolve and dilute to scale, shake well, take 1 ml accurately, put it in a 10ml measuring flask, dilute it to the scale with dichloromethane, and shake it well to serve as a control solution (3). According to the thin layer chromatography (General 0502) test, absorb the above four solutions of 10 u1, respectively, on the same silica gel GF254 thin layer plate, with dichloromethane-methanol-concentrated ammonia solution (190:10:1) for the development of the agent, expand, dry, set the UV light (254mn) under the inspection. The chromatogram of the control solution (3) should show two clear spots. Test solution such as impurity spots, respectively, compared with the control solution (1), (2) showed the main spot, there can be only one impurity spot color deeper than the control solution (1) the color of the main spot should not be deeper than the color of the main spot of the control solution (2), and other impurity spots should not be deeper than the main spot of the control solution (1). N-ethyl-methyl pyridinamine take 0.10g of this product, add 2ml of water, heat and dissolve, let cool, add 1 ml of acetaldehyde solution (1-20), shake, add 3~4 drops of sodium nitrosoferricyanide solution and 3~4 drops of sodium bicarbonate solution, shake, the solution should not show blue.
take l.Og of this product, put the phosphorus pentoxide dryer under reduced pressure and dry to constant weight, and the weight loss shall not exceed 0.3% (General rule 0831).
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).
take this product about 0.2g, precision weighing, add glacial acetic acid 25ml dissolved, add crystal violet indicator liquid 1 drop, with perchloric acid titration solution (0.1 mol/L titration to the solution showed blue-green, and the titration results were corrected by blank test. Each 1 ml perchloric acid titration solution (0.1 mol/L) corresponds to 28.44mg of C17H20NgO2.
mydriatic drugs.
light shielding, sealed storage.
This product is colorless and clear liquid.
Same as tropicamide.
(l)5ml:12.5mg (2)5ml:25mg (3)6ml:15mg (4)6ml:30mg
sealed storage.