(2R,3R)-2,3-dihydroxy-3-((4R,5R)-5-hydroxy-2-methyl-1,3-dioxan-4-yl)propanal

Name	4,6-O-ethylidene-alpha-D-glucose
Synonyms	NSC 89726 -D-glucopyranose Ethylideneglucose 4,6-O-ETHYLIDENE-A-D-GLUCOSE 4,6-O-ethylidenehexopyranose 4,6-O-ethylidene-alpha-D-glucose 4,6-O-ETHYLIDENE-ALPHA-D-GLUCOPYRANOSE 4,6-O-ethylidene-alpha-D-glucopyranose 4,6-O-[(1R)-ethylidene]-alpha-D-glucopyranose (4AR,7R,8R,8aS)-2-Methylhexahydropyrano-[3,2-d][1,3]dioxine-6,7,8-triol (4aR,6S,7R,8R,8aS)-2-Methylhexahydropyrano[3,2-d][1,3]dioxine-6,7,8-triol (2R,3R)-2,3-dihydroxy-3-((4R,5R)-5-hydroxy-2-methyl-1,3-dioxan-4-yl)propanal
CAS	13224-99-2
EINECS	236-198-2
InChI	InChI=1/C8H14O6/c1-3-12-2-4-7(13-3)5(9)6(10)8(11)14-4/h3-11H,2H2,1H3/t3-,4-,5-,6-,7-,8+/m1/s1

Molecular Formula	C8H14O6
Molar Mass	206.19
Density	1.446±0.06 g/cm3(Predicted)
Melting Point	168-170°C(lit.)
Boling Point	386.6±42.0 °C(Predicted)
Flash Point	>110°(230°F)
Water Solubility	almost transparency
Solubility	Ethanol, Water
Vapor Presure	0mmHg at 25°C
Appearance	Powder
Color	White to Off-white
pKa	12.01±0.70(Predicted)
Storage Condition	2-8℃
Refractive Index	1.539
MDL	MFCD00006820
In vitro study	4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose) shows poor affinity for malarial hexose transporter (PfHT1; K i >50 mM). 4,6-O-ethylidene-α-D-glucose inhibits wild-type transport with a K i of approximately 12 mM, but this is increased to greater than 120 mM in the Gln282-Leu mutant. 4,6-O-ethylidene-α-D-glucose inhibits glucose exit competitively but its penetration into human red cells is unaffected by glucose in the medium. The potentiation of the development of FDNB inhibition by sugars in the incubating medium is absent when 4,6-O-ethylidene-α-D-glucose is used and there is a slight protective action. 4,6-O-ethylidene-α-D-glucose penetrates human red cells by simple diffusion supported by its penetration of guinea-pig red cells at similar rates, by the occurrence of osmotic haemolysis in isosmotic solutions which is unaffected by copper ions and by the relatively high ether/water partition of the compound.

Safety Description	24/25 - Avoid contact with skin and eyes.
WGK Germany	3
HS Code	29400090

LogP	0.54
biological activity	4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose) is a glucose derivative, a competitive glucose transporter 1 (GLUT1) facial binding site inhibitor, The Ki value for wild-type 2-deoxy-D-glucose transport is 12 mM.

Last Update：2024-04-09 20:49:11

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Product Name: 4,6-O-Ethylidene-Alpha-D-Glucose Visit Supplier Webpage Request for quotation
CAS: 13224-99-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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(2R,3R)-2,3-dihydroxy-3-((4R,5R)-5-hydroxy-2-methyl-1,3-dioxan-4-yl)propanal Request for Quotation