(2R,3R)-BOC-dolaproine
(2R,3R)-BOC-dolaproine
CAS: 120205-50-7
Molecular Formula: C14H25NO5
(2R,3R)-BOC-dolaproine - Names and Identifiers
(2R,3R)-BOC-dolaproine - Physico-chemical Properties
| Molecular Formula | C14H25NO5 |
| Molar Mass | 287.35 |
| Density | 1.133±0.06 g/cm3(Predicted) |
| Boling Point | 397.8±17.0 °C(Predicted) |
| pKa | 4.27±0.11(Predicted) |
| Storage Condition | 2-8°C |
(2R,3R)-BOC-dolaproine - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.48 ml | 17.4 ml | 34.801 ml |
| 5 mM | 0.696 ml | 3.48 ml | 6.96 ml |
| 10 mM | 0.348 ml | 1.74 ml | 3.48 ml |
| 5 mM | 0.07 ml | 0.348 ml | 0.696 ml |
Last Update：2024-01-02 23:10:35
(2R,3R)-BOC-dolaproine - Reference Information
| Sea rabbit toxin | The Sea rabbit is a hermaphroditic organism, which inhabits the sea floor and is exposed, two male and female genital foramen between the egg groove connected. There are about 3000 species of this wonderful animal known, distributed in all parts of the world. scientists extracted a kind of "sea rabbit toxin" from the body of the sea rabbit, through animal experiments, that can be used as anti-cancer agents. This preparation only has a killing effect on cancer cells, and has no toxicity to normal cells. The appearance of sea rabbit anticancer preparations makes the sea rabbit famous. The origin of the sea rabbit toxin: one of the Marine Biological toxins, the digestive gland of the sea rabbit was found in the long tail of the long tail of the marine algae, so it was named as the sea rabbit toxin. It is a linear peptide natural cytotoxic protein, which is very little in the organism. Has a high anti-cancer effect. Structure of sea rabbit toxin: it is a kind of nonapeptide, which is very little in the organism. Up to now, 18 short chain peptide compounds containing special amino acids have been identified, named dolastatin 1~18. The structures of Dolastatin3,Dolastatin10(D10),Dolastatin15 were determined. D10 is one of the most studied, and D10 is generally used as a representative of the sea rabbit toxin. Introduction of Dolastatin10: D10 is a natural cytotoxic protein consisting of 4 amino acids, which contains 9 asymmetric carbon atoms, and the sequence from the amino terminus is dolavaline(Dov). valine, dolaisoleucine (Dil), dolaproine(Dap)4 kinds of amino acids and the specific primary amine dolaphenie(Doe) that may be isolated from phenylalanine as a carboxyl terminal condensation, therefore, some researchers call it a 5 peptide product with a relative molecular mass of 784. D10 has a series of isomers, some of which have biological effects. The natural D-10 yield is extremely small, and the existing synthetic methods and routes are limited to the laboratory scale and cannot meet the growing demand. The underlying reason for this is the inability to stereoselectively synthesize the most complex component of D-10, the Dolaproine(Dap) with three chiral centers. |
Last Update：2024-04-09 15:16:56
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CAS: 120205-50-7
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CAS: 120205-50-7
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Email: 3008007409@qq.com
Mobile: 18021002903
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