Name | (2R,3S)-E1R |
Synonyms | 3S)-E1R (2R,3S)-E1R 1-Pyrrolidineacetamide, 2-methyl-5-oxo-3-phenyl-, (2R,3S)- |
CAS | 1424832-60-9 |
Molecular Formula | C13H16N2O2 |
Molar Mass | 232.28 |
Density | 1.168±0.06 g/cm3(Predicted) |
Boling Point | 480.0±45.0 °C(Predicted) |
pKa | 15.67±0.40(Predicted) |
In vitro study | Sigma-1 receptor plays an important role in neuronal plasticity, a process implicated in the pathophysiology of neuropsychiatric diseases, such as Alzheimer’s disease, major depressive disorders, and schizophrenia. |
biological activity | (2R,3S)-E1R is an enantiomer of E1R (Compound 2c). (2R,3S)-E1R is a positive allosteric modulator of the sigma-1 receptor (Sig1R PAM) and is useful in the study of cognitive and memory disorders. |