(2S,3R,5S)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenl)methoxy)meth
5'-o-(4,4'-Dimethoxytrityl)-N4-acetyl-2deoxycytidine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
CAS: 154110-40-4
Molecular Formula: C41H50N5O8P
(2S,3R,5S)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenl)methoxy)meth - Names and Identifiers
(2S,3R,5S)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenl)methoxy)meth - Physico-chemical Properties
| Molecular Formula | C41H50N5O8P |
| Molar Mass | 771.84 |
| Appearance | powder |
| Color | white to off-white |
| pKa | 10.26±0.20(Predicted) |
| Storage Condition | -20°C |
(2S,3R,5S)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenl)methoxy)meth - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29349990 |
(2S,3R,5S)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenl)methoxy)meth - Introduction
Ac-dC phosphoramidite (N2-(acetoxyethyl)-N2-(3-chlorine)-N6-(3-(dimethylcarbamoyl)propyl)-9H-purine-2,6-diamine) is an organic compound, it is a DNA repair enzyme PARP (polymerase I reaction activation protein) inhibitor. The following is a description of the properties, uses, preparation and safety information of Ac-dC phosphoramidites:
1. Nature: Ac-dC phosphoramidite is a solid white crystal with good solubility. Its molecular formula is C20H24ClN9O2 and its relative molecular mass is 463.91g/mol.
2. Use: Ac-dC phosphoramidite as an inhibitor of PARP enzyme, can be used to inhibit the activity of DNA repair enzyme PARP in cells, thereby enhancing the killing effect of chemotherapy and radiotherapy on cancer cells. It has potential in cancer treatment and can be used to develop PARP enzyme inhibitor drugs.
3. Preparation method: The synthesis method of Ac-dC phosphoramidite is relatively complex, and it is generally synthesized by multi-step reaction. The specific synthesis method can refer to the relevant research literature and patents.
4. Safety Information: Ac-dC phosphoramidites need to pay attention to safety matters during use and storage. It is a chemical with certain toxicity and irritation, please keep away from children and fire sources. Appropriate personal protective equipment, such as lab gloves and goggles, should be worn during operation. Wastes and residues in the working environment should be handled and disposed of in accordance with relevant regulations. Please read carefully and follow the relevant safety operation procedures when using. Any use of chemicals should take into account their specific risks and safety measures.
1. Nature: Ac-dC phosphoramidite is a solid white crystal with good solubility. Its molecular formula is C20H24ClN9O2 and its relative molecular mass is 463.91g/mol.
2. Use: Ac-dC phosphoramidite as an inhibitor of PARP enzyme, can be used to inhibit the activity of DNA repair enzyme PARP in cells, thereby enhancing the killing effect of chemotherapy and radiotherapy on cancer cells. It has potential in cancer treatment and can be used to develop PARP enzyme inhibitor drugs.
3. Preparation method: The synthesis method of Ac-dC phosphoramidite is relatively complex, and it is generally synthesized by multi-step reaction. The specific synthesis method can refer to the relevant research literature and patents.
4. Safety Information: Ac-dC phosphoramidites need to pay attention to safety matters during use and storage. It is a chemical with certain toxicity and irritation, please keep away from children and fire sources. Appropriate personal protective equipment, such as lab gloves and goggles, should be worn during operation. Wastes and residues in the working environment should be handled and disposed of in accordance with relevant regulations. Please read carefully and follow the relevant safety operation procedures when using. Any use of chemicals should take into account their specific risks and safety measures.
Last Update：2024-04-09 19:05:46
Supplier List
Spot supply
Product Name: (2R,3S,5R)-5-(4-ACETAMIDO-2-OXOPYRIMIDIN-1(2H)-YL)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE Visit Supplier Webpage Request for quotationCAS: 154110-40-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Multiple Specifications
Product Name: 5'-O-DMT-N4-Acetyl-2'-deoxycytidine 3'-CE phosphoramidite Request for quotationCAS: 154110-40-4
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302
Product List: View Catalog
Spot supply
Product Name: (2R,3S,5R)-5-(4-ACETAMIDO-2-OXOPYRIMIDIN-1(2H)-YL)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE Visit Supplier Webpage Request for quotationCAS: 154110-40-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Multiple Specifications
Product Name: 5'-O-DMT-N4-Acetyl-2'-deoxycytidine 3'-CE phosphoramidite Request for quotationCAS: 154110-40-4
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302
Product List: View Catalog
View History