Molecular Formula | C17H15ClO2 |
Molar Mass | 286.75 |
Density | 1.225±0.06 g/cm3(Predicted) |
Melting Point | 114-115℃ |
Boling Point | 444.1±24.0 °C(Predicted) |
Solubility | DMSO: >20mg/mL |
Appearance | powder |
Color | white to off-white |
pKa | 4.55±0.10(Predicted) |
Storage Condition | 2-8°C |
Use | PS 48 has been shown to be a PKB Kinase (PDK1) activator (Kd: 10.3 μM). This compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1). |
WGK Germany | 3 |
Reference Show more | 1. Hindie V, et al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat Chem Biol. 2009 Oct;5(10):758-64.2. Han F, et al. Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway. Int J Biol Sci. 2017 Sep 21;13(10):1266-1275. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.487 ml | 17.437 ml | 34.873 ml |
5 mM | 0.697 ml | 3.487 ml | 6.975 ml |
10 mM | 0.349 ml | 1.744 ml | 3.487 ml |
5 mM | 0.07 ml | 0.349 ml | 0.697 ml |