(3-beta,4-alpha)-3,23-dihydroxyolean-12-en-28-oicacid
Hederagenin
CAS: 465-99-6
Molecular Formula: C30H48O4
(3-beta,4-alpha)-3,23-dihydroxyolean-12-en-28-oicacid - Names and Identifiers
(3-beta,4-alpha)-3,23-dihydroxyolean-12-en-28-oicacid - Physico-chemical Properties
| Molecular Formula | C30H48O4 |
| Molar Mass | 472.71 |
| Density | 0.9871 (rough estimate) |
| Melting Point | 332-334° |
| Boling Point | 493.44°C (rough estimate) |
| Specific Rotation(α) | D20 +81° (c = 0.7 in pyridine) |
| Flash Point | 324.319°C |
| Solubility | methanol: soluble1mg/mL |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White crystalline powder |
| Color | White to Off-White |
| Maximum wavelength(λmax) | ['405nm(H2SO4)(lit.)'] |
| Merck | 14,4624 |
| pKa | 4.63±0.70(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.4800 (estimate) |
| MDL | MFCD00017385 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol-ethanol, derived from HederanepalensisK.Kochvar. |
(3-beta,4-alpha)-3,23-dihydroxyolean-12-en-28-oicacid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29181990 |
(3-beta,4-alpha)-3,23-dihydroxyolean-12-en-28-oicacid - Reference
| Reference Show more | 1. Zhang Quan, Qi Meng Die Kang Ying, et al. Rapid identification of partial glycosides and aglycones in pericarp of Sapindus by UHPLC-LTQ Orbitrap MS [J]. Journal of Mass Spectrometry, 2018, 39(2):224-239. 2. Shi Bing, Yan, Li Xiang, Liu Yi, et al. Optimization of the hydrolysis process and spectrum analysis of the saponin of Ivy in the peel of the eight month melon [J]. Food and Fermentation Industries, 2020 046(002):239-245. 3. Zhao Shiyu, pen Xueyan, Yang pingyou, Kuang haixue, Wang Qiuhong, Lu shaowai. Analysis of active components in the anti-rheumatoid arthritis active fraction of Paeonia lutea based on HDAC3/8 molecular interaction technology [J]. Chinese herbal medicine, 2020,51(08):2117-2124. 4. Ma Xiaolin, Li Danxian, Wang Dong, etc. Analysis of the biosynthesis of the saponin of ivy and the construction of the yeast cell factory [J]. Chinese Journal of Traditional Chinese Medicine, 2018, 043(009):1844-1850. 5. Cao, Yanni, et al. "Chemical finger print and multicomponent quantitative analysis for the quality evaluation of Cyclocarya palm leaves by HPLC-Q-TOF-MS. Molecules 22.11 (2017): 1927.https://doi.org/10.3390/molecules22111927 6. [IF=4.411] Yanni Cao et al."Chemical Fingerprint and Multicomponent Quantitative Analysis for the Quality Evaluation of Cyclocarya paliurus Leaves by HPLC-Q-TOF-MS."Molecules. 2017 Nov;22(11):1927 7. [IF=3.935] Li Li et al."Rapid identification of urokinase plasminogen activator inhibitors from Traditional Chinese Medicines based on ultrafiltration, LC-MS and in silico docking."J Pharmaceut Biomed. 2019 Feb;164:241 8. [IF=5.645] Mingming Zhou et al."Geographical variations of triterpenoid contents in Cyclocarya paliurus leaves and their inhibitory effects on HeLa cells."Ind Crop Prod. 2021 Apr;162:113314 |
(3-beta,4-alpha)-3,23-dihydroxyolean-12-en-28-oicacid - Reference Information
| Plant source: | Ivy |
| biological activity | Hederagenin is triterpene saponin, which can inhibit the expression of iNOS, COX-2, and NF-κB caused by LPS stimulation in cells. |
| Target | Value |
| use | ivy sapogenin can be used as an inhibitor of protein tyrosine phosphatase PTP1B. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: It has the effect of stimulating mucosa, inhibiting proliferation, cycle arrest and inducing apoptosis of human promyelocytic leukemia cell HL-60. |
Last Update：2024-04-09 22:09:11
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