(3-fluorophenyl)(piperidin-4-yl)methanone

(3-fluorophenyl)(piperidin-4-yl)methanone - Names and Identifiers

Name	(3-fluorophenyl)(piperidin-4-yl)methanone
Synonyms	LogP 4-(3-FLUOROBENZOYL)PIPERIDINE (3-Fluorophenyl)(piperidin-4-yl)methanone (3-fluorophenyl)-(4-piperidinyl)methanone (3-fluorophenyl)(piperidin-4-yl)methanone Methanone, (3-fluorophenyl)-4-piperidinyl- methanone, (3-fluorophenyl)-4-piperidinyl- (3-Fluorophenyl)-4-piperidinyl-Methanone HCl 4-[(3-Fluorophenyl)carbonyl]piperidine hydrochloride (3-Fluorophenyl)-4-piperidinyl-methanone hydrochloride
CAS	639468-63-6
InChI	InChI=1/C12H14FNO/c13-11-3-1-2-10(8-11)12(15)9-4-6-14-7-5-9/h1-3,8-9,14H,4-7H2

(3-fluorophenyl)(piperidin-4-yl)methanone - Physico-chemical Properties

Molecular Formula	C12H14FNO
Molar Mass	207.24
Density	1.128±0.06 g/cm3(Predicted)
Boling Point	317.6±32.0 °C(Predicted)
Flash Point	145.9°C
Vapor Presure	0.00038mmHg at 25°C
pKa	9.67±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	1.522

(3-fluorophenyl)(piperidin-4-yl)methanone - Risk and Safety

Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

(3-fluorophenyl)(piperidin-4-yl)methanone - Introduction

(3-fluorophenyl)(piperidin-4-yl)methanone is an organic compound with a chemical formula of C16H16FNO and a molecular weight of 261.3g/mol. The following is a description of its nature, use, preparation and safety information:

Nature:
(3-fluorophenyl)(piperidin-4-yl)methanone is a solid compound with the appearance of white crystals. It is soluble in some organic solvents such as ethanol and dimethylformamide at room temperature. It has a melting point of about 86-87°C.

Use:
The compound is widely used in the field of medicinal chemistry. It is an important intermediate for the synthesis of a variety of drugs, such as antidepressants, antipsychotics and antiepileptic drugs. It can also be used as a catalyst and reagent in organic synthesis.

Preparation Method:
(3-fluorophenyl)(piperidin-4-yl) The preparation of methanone can be completed through a series of chemical reactions. A common method is to prepare (3-fluorophenyl)-4-piperidinylcarboxylic acid by fluorination reaction of hydrofluoric acid and ammonia gas, and then convert the acid to ketone by decarboxylation reaction.

Safety Information:
(3-fluorophenyl)(piperidin-4-yl)methanone are organic compounds, so they have certain safety risks. It can be irritating and toxic, with irritating effects on the eyes, skin and respiratory system. Appropriate personal protective equipment, such as lab gloves and respiratory protectors, should be worn during operation. At the same time, it should be operated in a well-ventilated place, away from fire and combustibles. Safe handling procedures should be followed and the compound should be stored and handled properly. When using or handling the compound, the relevant safety data sheets and instructions should be carefully read and followed.

Last Update：2024-04-09 21:11:58