(3R)-Pyrrolidine-3-ol
(R)-Hydroxypyrrolidine
CAS: 2799-21-5
Molecular Formula: C4H9NO
(3R)-Pyrrolidine-3-ol - Names and Identifiers
| Name | (R)-Hydroxypyrrolidine |
| Synonyms | (3R)-3-PYRROLIDINOL (3R)-Pyrrolidin-3-ol (R)-Pyrrolidine-3-ol (3R)-Pyrrolidine-3-ol (R)-Hydroxypyrrolidine (R)-(+)-3-PYRROLIDINOL (R)-3-Hydroxypyrrolidine (3R)-3-hydroxypyrrolidinium |
| CAS | 2799-21-5 |
| EINECS | 628-839-3 |
| InChI | InChI=1/C4H9NO/c6-4-1-2-5-3-4/h4-6H,1-3H2/p+1/t4-/m1/s1 |
(3R)-Pyrrolidine-3-ol - Physico-chemical Properties
| Molecular Formula | C4H9NO |
| Molar Mass | 87.12 |
| Density | 1.078 g/mL at 20 °C (lit.) |
| Melting Point | 15°C |
| Boling Point | 215-216 °C (lit.) |
| Specific Rotation(α) | 6.5 º (c=3.5% in MeOH) |
| Flash Point | >230°F |
| Water Solubility | Soluble in water and methanol. |
| Vapor Presure | 0.018mmHg at 25°C |
| Appearance | Viscous Liquid |
| Specific Gravity | 1.048 |
| Color | Clear yellow to orange-brown |
| BRN | 5376132 |
| pKa | 14.91±0.20(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Sensitive | Air Sensitive & Hygroscopic |
| Refractive Index | n20/D 1.488(lit.) |
(3R)-Pyrrolidine-3-ol - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-34 |
| HS Code | 29339900 |
| Hazard Note | Irritant |
(3R)-Pyrrolidine-3-ol - Introduction
(R)-Hydroxypyrrolidine ((R)-Hydroxypyrrolidine) is an organic compound with the chemical formula C5H11NO. It is a colorless to light yellow liquid with a stimulating ammoniacal odor at room temperature.
(R)-Hydroxypyrrolidine is a chiral compound. It has two enantiomers, (R)-Hydroxypyrrolidine and (S)-hydroxytetrahydropyrrole. Among them,(R)-Hydroxypyrrolidine is a naturally occurring form, which is also commonly used in drug synthesis and organic synthesis.
Because the molecular structure of (R)-Hydroxypyrrolidine contains hydroxyl and pyrrole ring, it has important application value in organic synthesis. It can be used as a catalyst, ligand or intermediate for the synthesis and modification of organic molecules, such as drugs, peptides, biologically active substances and so on.
The preparation method of (R)-Hydroxypyrrolidine is usually achieved by hydroxylation reaction. A common preparation method is to react pyrrole with ethylenediamine under appropriate reaction conditions to give (R)-Hydroxypyrrolidine.
Regarding safety information, although (R)-Hydroxypyrrolidine is widely used in laboratory environments, potential risks to humans and the environment still need to be handled carefully. It may be irritating, and contact with the skin and eyes may cause irritation or allergic reactions. Therefore, appropriate personal protective equipment such as lab gloves and goggles should be worn during use or handling. In addition, it should be stored in a dry, cool place, and away from fire and combustibles. It is best to read and follow the relevant safety instructions and operating procedures before use.
(R)-Hydroxypyrrolidine is a chiral compound. It has two enantiomers, (R)-Hydroxypyrrolidine and (S)-hydroxytetrahydropyrrole. Among them,(R)-Hydroxypyrrolidine is a naturally occurring form, which is also commonly used in drug synthesis and organic synthesis.
Because the molecular structure of (R)-Hydroxypyrrolidine contains hydroxyl and pyrrole ring, it has important application value in organic synthesis. It can be used as a catalyst, ligand or intermediate for the synthesis and modification of organic molecules, such as drugs, peptides, biologically active substances and so on.
The preparation method of (R)-Hydroxypyrrolidine is usually achieved by hydroxylation reaction. A common preparation method is to react pyrrole with ethylenediamine under appropriate reaction conditions to give (R)-Hydroxypyrrolidine.
Regarding safety information, although (R)-Hydroxypyrrolidine is widely used in laboratory environments, potential risks to humans and the environment still need to be handled carefully. It may be irritating, and contact with the skin and eyes may cause irritation or allergic reactions. Therefore, appropriate personal protective equipment such as lab gloves and goggles should be worn during use or handling. In addition, it should be stored in a dry, cool place, and away from fire and combustibles. It is best to read and follow the relevant safety instructions and operating procedures before use.
Last Update：2024-04-09 21:32:39
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