(3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone

Name	(3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone
Synonyms	(3R,4S)- Cabazitaxel Impurity 56 3-hydroxy-4-phenyl-2-azetidinone Cis-3-Hydroxy-4-Phenyl-2-Azetidinone CIS-3-HYDROXY-4-PHENYL-2-AZETIDINONE 4S)-3-Hydroxy-4-phenyl-2-azetidinone (3R,4S)-3-Hydroxy-4-Phenylazetidin-2-One (3R,4S)-3-HYDROXY-4-PHENYL-2-AZETIDINONE (3R,4S)-3-Hydroxy-4-phenylazetidin-2-one (3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone (3R-Cis)-3-Hydroxy-4-Phenyl-2-Azetidinone (3r-cis)-3-hydroxy-4-phenyl-2-azetidinone
CAS	132127-34-5
EINECS	1308068-626-2
InChI	InChI=1/C9H9NO2/c11-8-7(10-9(8)12)6-4-2-1-3-5-6/h1-5,7-8,11H,(H,10,12)/t7-,8+/m0/s1

Molecular Formula	C9H9NO2
Molar Mass	163.17
Density	1.308
Melting Point	187-188°C
Boling Point	430.4±45.0 °C(Predicted)
Specific Rotation(α)	[a]D25=+182o, c=0.65 in MeOH
Flash Point	214.107°C
Solubility	DMSO (Slightly), Methanol (Slightly)
Vapor Presure	0mmHg at 25°C
Appearance	White solid
Color	White to Off-White
pKa	11.86±0.40(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.612

overview	(3R,4S)-3-hydroxy-4-phenyl-2-azetinone, abbreviated as (-)β-lactam, it is a very potential chiral drug intermediate, it has two isomers namely (3R,4S) configuration and (3S,4R), of which (3R,4S) configuration isomer derivative paclitaxel side chain C- 13 is an important chiral precursor of docetaxel, one of the most promising new drugs for clinical chemotherapy of cancer.
application	(3R,4S)-3-hydroxy -4-phenyl -2-azetinone can be used as an intermediate in organic synthesis and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical and pharmaceutical synthesis process, mainly as paclitaxel side chain.

Last Update：2024-04-09 21:50:46