(3R,4S,5S,6R,7R,9R,11S,12R,13S,14R,Z)

(3R,4S,5S,6R,7R,9R,11S,12R,13S,14R,Z) - Names and Identifiers

Name	Clarithromycin (9Z)-O-Methyloxime
Synonyms	ClarithroMycin Identity Clarithromycin (9Z)-O-Methyloxime (3R,4S,5S,6R,7R,9R,11S,12R,13S,14R,Z) Erythromycin, 6-O-methyl-, 9-O-methyloxime, (9Z)- Clarithromycin Impurity 15(Clarithromycin EP Impurity O) (3R,4S,5S,6R,7R,9R,11S,12R,13S,14R,Z)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-12,13-dihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-7-methoxy-10-(methoxyimino)-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one
CAS	127252-80-6

(3R,4S,5S,6R,7R,9R,11S,12R,13S,14R,Z) - Physico-chemical Properties

Molecular Formula	C39H72N2O13
Molar Mass	776.99
Density	1.23±0.1 g/cm3(Predicted)
Melting Point	>116oC (dec.)
Boling Point	812.6±75.0 °C(Predicted)
Solubility	Chloroform (Slightly), Methanol (Very Slightly)
Appearance	Solid
Color	Off-White to Pale Beige
pKa	13.02±0.70(Predicted)
Storage Condition	Hygroscopic, -20°C Freezer, Under inert atmosphere
Stability	Hygroscopic

(3R,4S,5S,6R,7R,9R,11S,12R,13S,14R,Z) - Introduction

Clarithromycin (9Z)-O-Methyloxime, chemical name (Clarithromycin (9Z)-O-methoxamine) is a drug impurity. The following is some information on the nature, use, formulation and safety of Clarithromycin (9Z)-O-Methyloxime:

Nature:
Clarithromycin (9Z)-O-Methyloxime is an organic compound with a chemical formula of C37H64N2O16 and a relative molecular mass of 788.9g/mol. It belongs to a possible metabolite of the macrolide antibiotic clarithromycin. It is a white crystalline solid, stable at room temperature.

Use:
Clarithromycin (9Z)-O-Methyloxime has not been extensively studied or used clinically. In the research field, it may be used as an analytical standard for clarithromycin and its metabolites for pharmacokinetic studies or pharmacokinetic evaluation.

Preparation Method:
The preparation method of Clarithromycin (9Z)-O-Methyloxime is usually synthesized by chemical reaction. The specific preparation method may vary depending on the experimental conditions and research purposes.

Safety Information:
Since Clarithromycin (9Z)-O-Methyloxime has not been widely used or studied, detailed information about its safety and toxicity is unclear. When handling Clarithromycin (9Z)-O-Methyloxime, it is necessary to follow the principles of good laboratory practice and take appropriate protective measures, such as wearing laboratory gloves and protective glasses.

Last Update：2024-04-09 21:04:16