(3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine

(3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine - Names and Identifiers

Name	(3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine
Synonyms	(3S,4S)-N-Boc-4-hydroxypyrrolidine (3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine (3s,4s)-n-boc-3-amino-4-hydroxypyrrolidine 1-Boc-(3S,4S)-3-aMino-4-hydroxypyrrolidine tert-butyl (3S,4S)-3-amino-4-hydroxypyrrolidine-1-carboxylate (3S,4S)-tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate (3S,4S)-4-aMino-1-N-tert-butyloxycarbonyl-3-hydroxypyrrolidine (3S,4S)-3-Amino-4-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3S,4S)-(9CI)
CAS	190792-74-6

(3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine - Physico-chemical Properties

Molecular Formula	C9H18N2O3
Molar Mass	202.25
Density	1.179
Boling Point	308.8±42.0 °C(Predicted)
pKa	14.36±0.40(Predicted)
Storage Condition	2-8°C(protect from light)

(3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine - Introduction

(3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine (also known as Boc-3-amino-4-hydroxypyrrolidine) is an organic compound with the following properties:

1. Appearance: usually white or white solid.
2. Melting Point: about 70-73 degrees Celsius.
3. Molecular formula: C11H19N3O3.
4. Molecular weight: about 245.29g/mol.

The main uses of Boc-3-amino-4-hydroxypyrrolidine include:

1. Synthetic enzyme inhibitor: it can be used for synthetic enzyme inhibitors, such as anti-cancer drugs.
2. Synthesis of chiral drugs: It is a chiral molecule and can be used as an intermediate for the synthesis of chiral drugs.
3. Chemical synthesis intermediate: Due to the special structure of Boc-3-amino-4-hydroxypyrrolidine, it can be used as a synthetic intermediate for other organic compounds.

The preparation method of Boc-3-amino -4-hydroxyl pyrrolidine is generally as follows:

1. First, 3-amino-2-hydroxypyrrolidine and di-tert-butyl difluoroformate (Boc2O) were reacted under cooling conditions.
2. After completion of the reaction, potassium chloride (KCl) was added and stirring was continued.
3. Add acetic acid and alkaline activated deprotecting agent (such as sodium hydroxide) to remove the protecting group.
4. Finally, washing with water and crystallization gave Boc-3-amino-4-hydroxypyrrolidine.

Regarding safety information, Boc-3-amino-4-hydroxypyrrolidine is generally relatively safe under proper handling and storage conditions. However, it may cause irritation and damage to the eyes, skin and respiratory system. In use, it is recommended to take appropriate personal protective measures, such as wearing gloves, glasses and protective masks, to avoid contact with skin, eyes and inhalation.

In addition, Boc-3-amino -4-hydroxypyrrolidine should be stored in a dry, cool place, away from fire and combustibles.

Last Update：2024-04-09 21:04:16