(3S,4S)-tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate
(3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine
CAS: 190792-74-6
Molecular Formula: C9H18N2O3
(3S,4S)-tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate - Names and Identifiers
(3S,4S)-tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate - Physico-chemical Properties
| Molecular Formula | C9H18N2O3 |
| Molar Mass | 202.25 |
| Density | 1.179 |
| Boling Point | 308.8±42.0 °C(Predicted) |
| pKa | 14.36±0.40(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
(3S,4S)-tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate - Introduction
(3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine (also known as Boc-3-amino-4-hydroxypyrrolidine) is an organic compound with the following properties:
1. Appearance: usually white or white solid.
2. Melting Point: about 70-73 degrees Celsius.
3. Molecular formula: C11H19N3O3.
4. Molecular weight: about 245.29g/mol.
The main uses of Boc-3-amino-4-hydroxypyrrolidine include:
1. Synthetic enzyme inhibitor: it can be used for synthetic enzyme inhibitors, such as anti-cancer drugs.
2. Synthesis of chiral drugs: It is a chiral molecule and can be used as an intermediate for the synthesis of chiral drugs.
3. Chemical synthesis intermediate: Due to the special structure of Boc-3-amino-4-hydroxypyrrolidine, it can be used as a synthetic intermediate for other organic compounds.
The preparation method of Boc-3-amino -4-hydroxyl pyrrolidine is generally as follows:
1. First, 3-amino-2-hydroxypyrrolidine and di-tert-butyl difluoroformate (Boc2O) were reacted under cooling conditions.
2. After completion of the reaction, potassium chloride (KCl) was added and stirring was continued.
3. Add acetic acid and alkaline activated deprotecting agent (such as sodium hydroxide) to remove the protecting group.
4. Finally, washing with water and crystallization gave Boc-3-amino-4-hydroxypyrrolidine.
Regarding safety information, Boc-3-amino-4-hydroxypyrrolidine is generally relatively safe under proper handling and storage conditions. However, it may cause irritation and damage to the eyes, skin and respiratory system. In use, it is recommended to take appropriate personal protective measures, such as wearing gloves, glasses and protective masks, to avoid contact with skin, eyes and inhalation.
In addition, Boc-3-amino -4-hydroxypyrrolidine should be stored in a dry, cool place, away from fire and combustibles.
1. Appearance: usually white or white solid.
2. Melting Point: about 70-73 degrees Celsius.
3. Molecular formula: C11H19N3O3.
4. Molecular weight: about 245.29g/mol.
The main uses of Boc-3-amino-4-hydroxypyrrolidine include:
1. Synthetic enzyme inhibitor: it can be used for synthetic enzyme inhibitors, such as anti-cancer drugs.
2. Synthesis of chiral drugs: It is a chiral molecule and can be used as an intermediate for the synthesis of chiral drugs.
3. Chemical synthesis intermediate: Due to the special structure of Boc-3-amino-4-hydroxypyrrolidine, it can be used as a synthetic intermediate for other organic compounds.
The preparation method of Boc-3-amino -4-hydroxyl pyrrolidine is generally as follows:
1. First, 3-amino-2-hydroxypyrrolidine and di-tert-butyl difluoroformate (Boc2O) were reacted under cooling conditions.
2. After completion of the reaction, potassium chloride (KCl) was added and stirring was continued.
3. Add acetic acid and alkaline activated deprotecting agent (such as sodium hydroxide) to remove the protecting group.
4. Finally, washing with water and crystallization gave Boc-3-amino-4-hydroxypyrrolidine.
Regarding safety information, Boc-3-amino-4-hydroxypyrrolidine is generally relatively safe under proper handling and storage conditions. However, it may cause irritation and damage to the eyes, skin and respiratory system. In use, it is recommended to take appropriate personal protective measures, such as wearing gloves, glasses and protective masks, to avoid contact with skin, eyes and inhalation.
In addition, Boc-3-amino -4-hydroxypyrrolidine should be stored in a dry, cool place, away from fire and combustibles.
Last Update：2024-04-09 21:04:16
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Product Name: (3S,4S)-tert-Butyl-3-amino-4-hydroxypyrrolidine-1-carboxylate Visit Supplier Webpage Request for quotation
CAS: 190792-74-6
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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CAS: 190792-74-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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