Name | Peimine |
Synonyms | PEIMINE Peimine Verticin Verticine VERTICINE PAYNANTHEINE(SH) ISODIHYDROIMPERIALINE Dihydroisoimperialine (5α)-Cevane-3β,6α,20-triol Cevane-3,6,20-triol, (3β,5α,6α)- (3beta,5alpha,6alpha)-cevane-3,6,20-triol |
CAS | 23496-41-5 |
InChI | InChI=1/C27H45NO3/c1-15-4-7-25-27(3,31)21-6-5-17-18(20(21)14-28(25)13-15)11-22-19(17)12-24(30)23-10-16(29)8-9-26(22,23)2/h15-25,29-31H,4-14H2,1-3H3/t15-,16-,17+,18+,19-,20-,21-,22-,23+,24-,25-,26+,27-/m0/s1 |
Molecular Formula | C27H45NO3 |
Molar Mass | 431.66 |
Density | 1.18±0.1 g/cm3(Predicted) |
Melting Point | 223-224° |
Boling Point | 568.4±50.0 °C(Predicted) |
Specific Rotation(α) | D16 -19.4° (ethanol); D17 -20° (CHCl3) |
Flash Point | 275.3°C |
Solubility | Easily soluble in methanol, ethanol, chloroform and other organic solvents. |
Vapor Presure | 2.74E-15mmHg at 25°C |
Appearance | White needle crystal (methanol) |
Color | White to Off-White |
pKa | 9.5(at 25℃) |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
Refractive Index | 1.591 |
MDL | MFCD02259442 |
Physical and Chemical Properties | White crystals, soluble in chloroform, derived from Fritillaria thunbergii fritillarii. |
Safety Description | 24/25 - Avoid contact with skin and eyes. |
HS Code | 29420000 |
Reference Show more | 1. Yu Tian, Lian Xin Jie, Sun Youling, et al. Origin of Fritillaria thunbergii and content analysis after ex-situ introduction [J]. Journal of Chengdu University (Natural Science Edition), 2018, 37(04):36-38 49. 2. Wang Youdi, Shen Tu Ruisha, Pan Yingjie, Liang Zehua. Taking Fritillaria thunbergii as an example to study the new process of sulfur fumigation processing [J]. Journal of Shandong University of Traditional Chinese Medicine, 2020,44(05):576-579. 3. Wu Xiao. HPLC-ELSD Determination of Alkaloid Active Components in Fritillaria thunbergii after Mutation Breeding [J]. Ginseng Research, 2020,32(05):43-46. 4. Cheng Bin, Zhou Aizhen, Peng Xin, Wang Xinlei, Wang Juan. Establishment of UPLC-Q-TOF-MS/MS Fingerprint of Fritillaria thunbergii and Analysis of Anti-inflammatory Quality Markers [J]. Chinese pharmacy, 2020,31(17):2129-2135. 5. [IF = 3.373] Issac Chi-Chung Cheng et al."Application of UPLC-MS/MS to simultaneously detect four bioactive compounds in the tumour-shrinking decoction (FM1523) for uterine fibroids treatment." Phytochem Analysis. 2019 Jul;30(4):447-455 6. [IF = 5.645] ning sui et al."Estimating Fritillaria thunbergii Miq. yield, quality, and potassium use efficiency in response to potassium application rate." Ind Crop Prod. 2021 Jun;164:113409 7. [IF = 3] Qu Lala et al."Phenotypic assessment and screening of ETA/ETB receptors with label-free dynamic mass redistribution say." N-S Arch Pharmacol. 2020 Jun;393(6):937-950 8. [IF = 2.289] Zhou Shun et al."Anthelmintic efficacy of natural saponins against Gyrodactylus kobayashii in goldfish (Carassius auratus) and their 3D-QSAR analysis." Parasitol Res. 2021 Mar;120(3):1143-1150 9. [IF = 5.34] Dong Shao et al."Identification of the active compounds and functional mechanisms of Jinshui Huanxian formula in pulmonary fibrosis by integrating serum pharmacochemistry with network pharmacology." PHYTOMEDICINE. 2022 Jul;102:154177 |
Efficacy and role | Fritillaria A is one of the main medicinal components of Fritillaria antiasthmatic. Recent studies have shown that Fritillaria A plays a role by inhibiting the active efflux pump on the bacterial cell membrane, and has a strong reversal effect on drug-resistant Staphylococcus aureus; in addition, Fritillaria can inhibit the proliferation and metastasis of tumor cells, inhibition of orbital fibroblast proliferation in patients with thyroid-associated ophthalmopathy. |
biological activity | fritillarin (Peimine; Verticine) is a natural compound with good anti-inflammatory activity. |
use | fritillin has the effects of clearing heat and moistening lung, relieving cough and reducing phlegm, followed by lowering blood pressure and anti-tumor. A traditional Chinese medicine alkaloid with anti-inflammatory effect. |