Name | Protopanaxadiol |
Synonyms | Protopanaxdiol Protopanaxadiol 20R-Protopanaxadiol (20R)-Protopanaxadiol 20R-Betulafolienetriol PROTOVERATRINE A+B (RG)(CALL) (20R)-Dammar-24-ene-3β,12β,20-triol (20R)-5α-Dammar-24-ene-3β,12β,20-triol Dammar-24-ene-3,12,20-triol, (3beta,12beta,20R)- (3beta,5xi,12beta,14beta,20R)-dammar-24-ene-3,12,20-triol |
CAS | 7755-01-3 |
InChI | InChI=1/C30H52O3/c1-19(2)10-9-14-30(8,33)20-11-16-29(7)25(20)21(31)18-23-27(5)15-13-24(32)26(3,4)22(27)12-17-28(23,29)6/h10,20-25,31-33H,9,11-18H2,1-8H3/t20-,21+,22?,23+,24-,25-,27-,28+,29-,30+/m0/s1 |
Molecular Formula | C30H52O3 |
Molar Mass | 460.73 |
Density | 1.036±0.06 g/cm3(Predicted) |
Melting Point | 236-238°C |
Boling Point | 559.5±40.0 °C(Predicted) |
Specific Rotation(α) | +20.5 (CHCl3) |
Flash Point | 226.1°C |
Solubility | Soluble in acetone, DMSO and other solvents. |
Vapor Presure | 7.57E-15mmHg at 25°C |
Appearance | White crystal |
pKa | 14.96±0.70(Predicted) |
Storage Condition | Sealed in dry,2-8°C |
Refractive Index | 1.528 |
MDL | MFCD12032048 |
Physical and Chemical Properties | White powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from ginseng. |
Reference Show more | 1. Su Wenjie, Zhang Yuyao, Li Rongsen, Wang Dishu, Xu Yunfeng, Zhang He. Hemostatic effect and mechanism of 20(S)-protopanaxadiol [J]. Chinese traditional medicines, 2021,43(03): -612 2. Zhang H, Pan D, Wu X, Su W, Tang X, Zhao D, Sun L, Song B, Bai X, Li X. Platelet Protease Activated Receptor 1 Is evolved in the lethal Effect of 20(S)-Protopanaxadiol by regulatory Calcium Signaling. Front Pharmacol. 2020 Sep 18;11:549150. doi: 10.33 3. [IF = 6.06] Jiahong Han et al."Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis."J Ginseng Res. 2020 Mar;44:291 4. [IF=6.06] Zhenzhuo Li et al."Ginsenosides repair UVB-induced skin barrier damage in BALB/c hairless mice and HaCaT keratinocytes."J Ginseng Res. 2021 May;: 5. [IF=6.023] Tiehua Zhang et al."Identification of 20(R, S)-protopanaxadiol and 20(R, S)-protopanaxatriol for potential selective modulation of glucocorticoid receptor."Food Chem Toxicol. 2019 Sep;131:110642 6. [IF=5.81] Zhang He et al."Platelet Protease Activated Receptor 1 Is Involved in the Hemostatic Effect of 20(S)-Protopanaxadiol by Regulating Calcium Signaling."Front Pharmacol. 2020 Sep;0:1483 7. [IF=5.396] Hui Wang et al."Ginsenoside extract from ginseng extends lifespan and health span in Caenorhabditis elegans."Food Funct. 2021 Aug;12(15):6793-6808 8. [IF=5.279] Yanan Gao et al."Galactosylation of Monosaccharide Derivatives of Glycyrrhetinic Acid by UDP-Glycosyltransferase GmSGT2 from Glycine max."J Agr Food Chem. 2020;68(32):8580-8588 9. [IF=4.679] Tiehua Zhang et al."20(S)-Protopanaxadiol blocks cell cycle progression by targeting epidermal growth factor receptor."Food Chem Toxicol. 2020 Jan;135:111017 10. [IF=4.24] Yuan Liang et al."Multi-spectroscopic and molecular modeling studies on the interactions of serum albumin with 20(S, R)-protopanaxadiol and 20(S, R)-protopanaxatriol that inhibit HCT-116 cells proliferation."Food Biosci. 2021 Apr;40:100913 11. [IF=3.645] Hao Zhang et al."Preparing molecularly imprinted nanoparticles of saponins via cooperative imprinting strategy."J Sep Sci. 2020 Jun;43(11):2162-2171 12. [IF=2.629] Zhang Meiyu et al."In Vitro Transformation of Protopanaxadiol Saponins in Human Intestinal Flora and Its Effect on Intestinal Flora."Evid-Based Compl Alt. 2021;2021:1735803 13. [IF=2.547] Zhongyi Cong et al."Ginsenoside Rh3 Inhibits Proliferation and Induces Apoptosis of Colorectal Cancer Cells."Pharmacology. 2020;105(5-6):329-338 14. [IF=5.753] Jianghong Gao et al."Molecular Cloning and Functional Characterization of a Sterol 3-O-Glucosyltransferase Involved in Biosynthesis of Steroidal Saponins in Trigonella foenum-graecum.."Front Plant Sci. 2021 Dec;12:809579-809579 15. [IF=6.06] Zhu Zhu et al."Target engagement of ginsenosides in mild cognitive impairment using mass spectrometry-based drug affinity responsive target stability."J Ginseng Res. 2021 Dec;: 16. [IF=5.396] Ye-Wei Huang et al."20(S)-protopanaxadiol decreases atherosclerosis in the ApoE KO mice by increasing the levels of LDLR and inhibiting its binding with PCSK9."Food & Function. 2022 May ;: |