(4-Bromopyridin-2-yl)methanol
4-Bromo-2-pyridinemethanol
CAS: 131747-45-0
Molecular Formula: C6H6BrNO
(4-Bromopyridin-2-yl)methanol - Names and Identifiers
| Name | 4-Bromo-2-pyridinemethanol |
| Synonyms | 4-BROMO-2-PYRIDINEMETHANOL 4-Bromo-2-pyridinemethanol 4-Bromopyridine-2-methanol (4-BroMo-2-pyridyl)Methanol 2-Pyridinemethanol, 4-bromo- 4-Bromopyridine-2-methano... (4-Bromopyridin-2-yl)methanol 4-BroMo-2-pyridineMethanol HCl 1-(4'-bromopyridin-2'-yl)methanol |
| CAS | 131747-45-0 |
| InChI | InChI=1/C6H6BrNO/c7-5-1-2-8-6(3-5)4-9/h1-3,9H,4H2 |
(4-Bromopyridin-2-yl)methanol - Physico-chemical Properties
| Molecular Formula | C6H6BrNO |
| Molar Mass | 188.02 |
| Density | 1.668±0.06 g/cm3(Predicted) |
| Melting Point | 52.0 to 56.0 °C |
| Boling Point | 105°C/0.5mmHg(lit.) |
| Flash Point | 125.7°C |
| Vapor Presure | 0.00141mmHg at 25°C |
| Appearance | powder to lump |
| Color | White to Light yellow to Light orange |
| pKa | 13.09±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.598 |
(4-Bromopyridin-2-yl)methanol - Introduction
2-hydroxymethyl-4-bromopyridine, chemical formula C6H6BrNO, is an organic compound. The following describes its nature, use, formulation and safety information:
Nature:
2-Hydroxymethyl-4-bromopyridine is a colorless to light yellow solid with a distinctive odor. It is relatively stable at room temperature and pressure, soluble in organic solvents such as ethanol and ether, slightly soluble in water.
Use:
2-hydroxymethyl-4-bromopyridine is an important raw material widely used in organic synthesis. It can be used as an intermediate for preparing ketone compounds, alcohol compounds, amine compounds, etc. In addition, it can also be used as an important raw material for the preparation of drugs, pesticides and dyes.
Preparation Method:
2-hydroxymethyl-4-bromopyridine can be synthesized by means of bromopyridine. First, pyridine is reacted with bromine using cuprous bromide (CuBr2) in the presence of a base to obtain 2-bromopyridine. Next, 2-bromopyridine is reacted with methanol under basic conditions to synthesize 2-hydroxymethyl-4-bromopyridine.
Safety Information:
2-hydroxymethyl-4-bromopyridine is generally stable under normal operating conditions, but the following safety precautions should be paid attention:
1. It is irritating and should avoid contact with skin, eyes and mucous membranes. If contact with the skin, should promptly rinse with plenty of water, and seek medical help.
2. during use, good ventilation should be maintained to avoid inhalation of its vapor or dust. If inhaled, immediately move to fresh air and seek medical help.
3. during handling, storage and transportation, contact with oxidants, acids and alkalis should be avoided to prevent dangerous reactions.
4. Please store and handle the compound according to the correct operation method and safety measures to avoid fire and high temperature environment.
Nature:
2-Hydroxymethyl-4-bromopyridine is a colorless to light yellow solid with a distinctive odor. It is relatively stable at room temperature and pressure, soluble in organic solvents such as ethanol and ether, slightly soluble in water.
Use:
2-hydroxymethyl-4-bromopyridine is an important raw material widely used in organic synthesis. It can be used as an intermediate for preparing ketone compounds, alcohol compounds, amine compounds, etc. In addition, it can also be used as an important raw material for the preparation of drugs, pesticides and dyes.
Preparation Method:
2-hydroxymethyl-4-bromopyridine can be synthesized by means of bromopyridine. First, pyridine is reacted with bromine using cuprous bromide (CuBr2) in the presence of a base to obtain 2-bromopyridine. Next, 2-bromopyridine is reacted with methanol under basic conditions to synthesize 2-hydroxymethyl-4-bromopyridine.
Safety Information:
2-hydroxymethyl-4-bromopyridine is generally stable under normal operating conditions, but the following safety precautions should be paid attention:
1. It is irritating and should avoid contact with skin, eyes and mucous membranes. If contact with the skin, should promptly rinse with plenty of water, and seek medical help.
2. during use, good ventilation should be maintained to avoid inhalation of its vapor or dust. If inhaled, immediately move to fresh air and seek medical help.
3. during handling, storage and transportation, contact with oxidants, acids and alkalis should be avoided to prevent dangerous reactions.
4. Please store and handle the compound according to the correct operation method and safety measures to avoid fire and high temperature environment.
Last Update：2024-04-09 21:01:54
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