(4-chlorophenyl)-pyridin-2-ylMethanone
(4-chlorophenyl) 2-pyridyl ketone
CAS: 6318-51-0
Molecular Formula: C12H8ClNO
(4-chlorophenyl)-pyridin-2-ylMethanone - Names and Identifiers
| Name | (4-chlorophenyl) 2-pyridyl ketone |
| Synonyms | Einecs 228-662-8 Carbinoxamine USP RC A (4-chlorophenyl)2-pyridyl ketone 4-chlorophenyl-2-pyridylmethanon (4-Chlorophenyl) 2-pyridyl ketone (4-chlorophenyl) 2-pyridyl ketone (4-Chlorophenyl)(2-pyridinyl)methanone (4-chlorophenyl)-pyridin-2-ylMethanone |
| CAS | 6318-51-0 |
| EINECS | 228-662-8 |
| InChI | InChI=1/C12H8ClNO/c13-10-6-4-9(5-7-10)12(15)11-3-1-2-8-14-11/h1-8H |
(4-chlorophenyl)-pyridin-2-ylMethanone - Physico-chemical Properties
| Molecular Formula | C12H8ClNO |
| Molar Mass | 217.65 |
| Density | 1.260±0.06 g/cm3(Predicted) |
| Melting Point | 62.0 to 66.0 °C |
| Boling Point | 160°C/0.6mmHg(lit.) |
| Solubility | soluble in Methanol |
| Appearance | powder to crystal |
| Color | White to Light yellow |
| pKa | 2.69±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
(4-chlorophenyl)-pyridin-2-ylMethanone - Risk and Safety
| HS Code | 2933399090 |
(4-chlorophenyl)-pyridin-2-ylMethanone - Introduction
(4-chlorophenyl) 2-pyridyl ketone is an organic compound with the chemical formula C12H8ClNO. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
(4-chlorophenyl) 2-pyridyl ketone is a white crystalline solid with a high melting point. It is almost insoluble in water at normal temperature, but soluble in organic solvents such as ethanol and methylene chloride.
Use:
The compound is commonly used as a reagent in organic synthesis, especially in metal-catalyzed reactions. It can be used as a ligand to participate in a variety of metal-catalyzed reactions, and can promote the formation of carbon-carbon and carbon-oxygen bonds, thereby synthesizing various organic compounds.
Preparation Method:
(4-chlorophenyl) 2-pyridyl ketone is synthesized by many methods. the commonly used method is to react the chlorine atom on the benzene ring with 2-pyridone by metal catalyst in the electrophilic aromatic substitution reaction.
Safety Information:
(4-chroophenyl) 2-pyridyl ketone is not particularly dangerous under normal conditions of use. However, as with any chemical, attention should be paid to safe handling, such as wearing appropriate personal protective equipment (such as gloves, goggles, etc.) and avoiding contact with skin and eyes. At the same time, it should be stored in a cool and dry place, and away from fire and flammable materials. If exposed or ingested, seek medical attention immediately.
Nature:
(4-chlorophenyl) 2-pyridyl ketone is a white crystalline solid with a high melting point. It is almost insoluble in water at normal temperature, but soluble in organic solvents such as ethanol and methylene chloride.
Use:
The compound is commonly used as a reagent in organic synthesis, especially in metal-catalyzed reactions. It can be used as a ligand to participate in a variety of metal-catalyzed reactions, and can promote the formation of carbon-carbon and carbon-oxygen bonds, thereby synthesizing various organic compounds.
Preparation Method:
(4-chlorophenyl) 2-pyridyl ketone is synthesized by many methods. the commonly used method is to react the chlorine atom on the benzene ring with 2-pyridone by metal catalyst in the electrophilic aromatic substitution reaction.
Safety Information:
(4-chroophenyl) 2-pyridyl ketone is not particularly dangerous under normal conditions of use. However, as with any chemical, attention should be paid to safe handling, such as wearing appropriate personal protective equipment (such as gloves, goggles, etc.) and avoiding contact with skin and eyes. At the same time, it should be stored in a cool and dry place, and away from fire and flammable materials. If exposed or ingested, seek medical attention immediately.
Last Update：2024-04-10 22:29:15
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