(4-methoxyphenyl)-thioure

(4-methoxyphenyl)-thioure - Names and Identifiers

Name	1-(4-methoxyphenyl)-2-thiourea
Synonyms	4-Methoxyphenylthiourea 4-METHOXYPHENYLTHIOUREA p-Methoxyphenyl thiourea (4-methoxyphenyl)-thioure N-(4-METHOXYPHENYL)THIOUREA 1-(4-methoxyphenyl)thiourea 1-(4-METHOXYPHENYL)-2-THIOUREA 1-(4-methoxyphenyl)-2-thiourea
CAS	2293-07-4
EINECS	218-931-8
InChI	InChI=1/C8H10N2OS/c1-11-7-4-2-6(3-5-7)10-8(9)12/h2-5H,1H3,(H3,9,10,12)

(4-methoxyphenyl)-thioure - Physico-chemical Properties

Molecular Formula	C8H10N2OS
Molar Mass	182.24
Density	1.287±0.06 g/cm3(Predicted)
Melting Point	223-225 °C
Boling Point	311.0±44.0 °C(Predicted)
Flash Point	141.9°C
Vapor Presure	0.00058mmHg at 25°C
Appearance	powder to crystal
Color	White to Light yellow to Light orange
BRN	777238
pKa	13.13±0.70(Predicted)
Storage Condition	Room Temprature
Refractive Index	1.677
MDL	MFCD00004936
Physical and Chemical Properties	Solid. The melting point was 212 °c (decomposition).
Use	Used as a dye intermediate

(4-methoxyphenyl)-thioure - Risk and Safety

Risk Codes	23/24/25 - Toxic by inhalation, in contact with skin and if swallowed.
Safety Description	S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S38 - In case of insufficient ventilation, wear suitable respiratory equipment. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S28A - S36/37 - Wear suitable protective clothing and gloves.
UN IDs	2811
RTECS	YT6825000
Hazard Note	Irritant
Hazard Class	6.1
Packing Group	II

(4-methoxyphenyl)-thioure - Reference Information

Use

Used as an intermediate in organic synthesis, mainly used in the dye industry.
Used as dye intermediate

Production method

It is obtained by the addition of p-methoxyaniline hydrochloride and sodium thiocyanate. Add 350L of water to the glass-lined reaction pot, heat to 60 ℃, and add 220kg p-methoxyaniline under stirring to completely dissolve it. Then 220kg of 30% industrial hydrochloric acid was added to make the feed liquid slightly blue to Congo red test paper. After 10min, 166.7kg (calculated as 100%) of sodium thiocyanate was added. Heating, slowly heating to 105 ℃, reflux 24h. Then it is cooled to below 25°C and filtered, the filter cake is washed with water, and dried to obtain 300kg of p-methoxyphenyl thiourea.

Last Update：2024-04-09 02:00:07