(4R)-4-Hydroxy-N,N-diphenyl-2-pentynamide
4-hydroxy-N,N-diphenyl-(4R)-2-Pentynamide
CAS: 899809-61-1
Molecular Formula: C17H15NO2
(4R)-4-Hydroxy-N,N-diphenyl-2-pentynamide - Names and Identifiers
(4R)-4-Hydroxy-N,N-diphenyl-2-pentynamide - Physico-chemical Properties
| Molecular Formula | C17H15NO2 |
| Molar Mass | 265.31 |
| Density | 1?+-.0.06 g/cm3(Predicted) |
| Boling Point | 411.9±47.0 °C(Predicted) |
| pKa | 13.24±0.20(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
(4R)-4-Hydroxy-N,N-diphenyl-2-pentynamide - Nature
| boiling point | 411.9±47.0 °C(Predicted) |
| density | 1? -. 0.06 g/cm3(Predicted) |
| storage conditions | Sealed in dry,Room Temperature |
| acidity coefficient (pKa) | 13.24±0.20(Predicted) |
Last Update：2024-04-09 21:04:16
(4R)-4-Hydroxy-N,N-diphenyl-2-pentynamide - Reference Information
| application | vorapasa M-4 can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development and chemical production. |
| preparation | 100ml eggplant bottle was sequentially added with (R)-3-butyne -2-alcohol (8.0g,0.114mol), THF(50ml), concentrated sulfuric acid (1 drop) and HMDS(29.6g,0.18mol), and the obtained white suspension was heated and refluxed for 4 hours. Add n-butyl lithium (2.5M,55ml,0.14mol) dropwise at -50 ~-40 ℃ to obtain light yellow clear liquid, and continue stirring for 1h. The mixed solution of THF(218ml) and toluene (87ml) of N,N-diphenyl-1H-imidazol-1-formamide (36g,0.136mol) was added dropwise to obtain orange clear liquid, quenched with 5N sulfuric acid (123ml,0.308mol), and stirred at 30 ℃ for 1h. In liquid separation, the organic phase is washed with 5N sulfuric acid (12.6ml,0.063mol) and saturated sodium chloride aqueous solution (32.0ml × 2), then the pH is adjusted with sodium bicarbonate solution to 7, and concentrated under reduced pressure to dry yellow solid Volapasa M-4 crude 32g. Toluene (30ml) was added to the crude product (10g,0.038mol) of Volapasa M-4, heated and refluxed for 2h, cooled to room temperature, filtered, vacuum dried to obtain 24.0g of yellow solid with a yield of 79.2%. |
Last Update：2024-04-09 19:05:03
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