(4R)-Oleana-11,13(18)-diene-3β,16α,23,28-tetrol

Name	SAIKOGENIN D
Synonyms	SAIKOGENIN D (4R)-Oleana-11,13(18)-diene-3β,16α,23,28-tetrol (3S,4R,6aR,6bS,8R,8aS,14aR,14bS)-4,8a-Bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-octadecahydropicene-3,8-diol
CAS	5573-16-0

Molecular Formula	C30H48O4
Molar Mass	472.7
Density	1.16±0.1 g/cm3(Predicted)
Melting Point	261-266 °C
Boling Point	607.4±55.0 °C(Predicted)
Appearance	Powder
pKa	14.47±0.70(Predicted)
Storage Condition	2-8℃
In vitro study	Saikogenin D (1-20 μM) inhibits PGE2 production induced by the Ca 2+ ionophore A23187 in a concentration-dependent manner with an IC 50 value of 3 μM in C6 rat glioma cells. Saikogenin D (10-100 μM) elevates [Ca 2+ ]i in a concentration-dependent manner with a EC 50 value of 35 μM in the presence or absence of extracellular Ca2+ in C6 rat glioma cells.

biological activity	Saikogenin d is isolated from Bupleurum chinense and has anti-inflammatory effect. Saikogenin D activates cyclooxygenase, converting arachidonic acid to epoxyeicosanoic acid and dihydroxyeicosatrienoic acid, whose metabolites in turn inhibit the production of prostaglandin E2 (PGE2). Saikogenin D leads to an increase in [Ca2 +] I due to intracellular Ca2 + release.
in vitro study	Saikogenin D (1-20 μM) inhibits PGE2 production induced by the Ca 2 ionophore A23187 in a concentration-dependent manner with an IC 50 value of 3 μM in C6 rat glioma cells. Saikogenin D (10-100 μM) elevates [Ca 2] I in a concentration-dependent manner with a EC 50 value of 35 μM in presence or absence of extracellular Ca2 in C6 rat glioma cells.

Last Update：2024-04-09 21:11:58

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