(4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-4,6-dien-3-one
Dihydrocurcumin
CAS: 76474-56-1
Molecular Formula: C21H22O6
(4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-4,6-dien-3-one - Names and Identifiers
(4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-4,6-dien-3-one - Physico-chemical Properties
| Molecular Formula | C21H22O6 |
| Molar Mass | 370.4 |
| Density | 1.277±0.06 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 179-180℃ |
| Boling Point | 616.3±55.0 °C(Predicted) |
| Solubility | Insoluble in water, soluble in ethanol, propylene glycol, soluble in glacial acetic acid and alkali solution. |
| Appearance | Yellow powder |
| pKa | 8.35±0.60(Predicted) |
| Storage Condition | 2-8℃ |
| Physical and Chemical Properties | Orange powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from turmeric. |
| Use | Dihydrocurcumin has antibacterial, anti-inflammatory, anti-tumor, antioxidant and hypolipidemic effects. |
(4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-4,6-dien-3-one - Reference
| Reference Show more | 1. Yu Qingqing, Meng Moran, Liu yanyuncheng, Yinxiang, Chen Yong. Preventive effect and mechanism of dihydrocurcumin on oleic acid-induced nonalcoholic fatty liver disease in vitro [J]. Chinese herbal medicine 2018 49(05):1092-1099. 2. Wu Gang, Chen Xinjun, Zhang Wanli, Li Fen. Effects of dihydrocurcumin on apoptosis pathway in BRL-3A cells in vitro [J]. Journal of Practical Hepatology, 2020,23(05):622-625. 3. [IF = 1.902] Jun Jun Wang et al."The pharmacoid and tissue distribution of currumin and its metabolites in mice." Biomed Chromatogr. 2018 Sep;32(9):e4267 4. [IF = 5.81] Wang Peijian et al."Comparing the Effect Piperine and Ilepcimide on the Pharmacokinetics of Curcumin in SD Rats."Front Pharmacol. 2021 Oct;0:2761 5. [IF=4.946] Lai Yanni et al."3D-quantitative structure-activity relationship and antiviral effects of curcumin derivatives as potent inhibitors of influenza H1N1 neuraminidase."Arch Pharm Res. 2020 May;43(5):489-502 |
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