(4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oicacidδ-lactone
Withaferin A
CAS: 5119-48-2
Molecular Formula: C28H38O6
(4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oicacidδ-lactone - Names and Identifiers
(4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oicacidδ-lactone - Physico-chemical Properties
| Molecular Formula | C28H38O6 |
| Molar Mass | 470.6 |
| Density | 1.28 |
| Melting Point | 252-253℃ |
| Boling Point | 680.7±55.0 °C(Predicted) |
| Specific Rotation(α) | D28 +125° (c = 1.30 in CHCl3) |
| Flash Point | 226℃ |
| Solubility | Soluble in DMSO (up to 20 mg/ml) |
| Appearance | White solid |
| Color | White |
| pKa | 13.49±0.70(Predicted) |
| Storage Condition | Desiccate at -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| Sensitive | Sensitive to air |
| In vitro study | Withaferin A has antiinflammatory activity, and potently inhibits NF-kB activation by preventing the TNF-induced activation of Ik-B kinase beta via a thioalkylation-sensitive redox mechanism. Withaferin A also has anticancer activity. Withaferin A targets the IF protein vimentin, causes aggregation of vimentin filaments in bovine aortic endothelial cells (BAECs) at 3 μM, and induces vimentin fragmentation in endothelial cells at 10 μM. Withaferin A (0.5, 1.5 μM) alone or incombination with cisplatin (CIS) dose-dependently reduces tumorigenic potential of ALDH1 positive cancer stem cells (CSCs). |
| In vivo study | Withaferin A (2 mg/kg, i.p.) shows potent angiogenesis inhibitory activity via vimentin in mice. Withaferin A (2 mg/kg) combined with cisplatin (CIS) regulates the expression of ALDH1 marker, and downregulates the expression of securin in tumors collected from mice. |
(4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oicacidδ-lactone - Risk and Safety
| Hazard Symbols | T - Toxic |
| WGK Germany | 3 |
| RTECS | KE7288500 |
| HS Code | 29322090 |
(4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oicacidδ-lactone - Reference Information
| biological activity | Withaferin A (WA, WFA) TNF-κB activation can be effectively inhibited by preventing tumor necrosis factor-induced activation of IκB kinase β through a redox mechanism that is sensitive to thioalkylation. Withafrin A binds to intermediate filament protein (IF) vimentin and has anti-tumor and anti-angiogenic activity. Withafrin A is A steroidal lactone isolated from within A somnifera. |
| Target | Value |
Last Update：2024-04-09 02:00:12
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Spot supply
Product Name: Withaferin A Visit Supplier Webpage Request for quotationCAS: 5119-48-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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