(5-chloro-1-benzothiophen-3-yl)methanamine

(5-chloro-1-benzothiophen-3-yl)methanamine - Names and Identifiers

Name	(5-Chloro-1-benzothiophen-3-yl)methylamine
Synonyms	RARECHEM AL BW 1019 5-CHLOROBENZOTHIOPHENE-3-METHYLAMINE 5-Chlorobenzo[b]thiophen-3-ylmethylamine (5-chloro-1-benzothiophen-3-yl)methanamine (5-Chloro-1-benzothiophen-3-yl)methylamine (5-CHLORO-1-BENZOTHIOPHEN-3-YL)METHYLAMINE (5-CHLORO-1-BENZOTHIOPHENE-3-YL)METHYLAMINE 1-(5-chloro-1-benzothiophen-3-yl)methanamine (5-CHLORO-1-BENZOTHIOPHEN-3-YL)METHYLAMINE HYDROCHLORIDE (5-chloro-1-benzothiophen-3-yl)methylamine hydrochloride 1-(5-chloro-1-benzothiophen-3-yl)methanamine hydrochloride
CAS	71625-90-6
InChI	InChI=1/C9H8ClNS/c10-7-1-2-9-8(3-7)6(4-11)5-12-9/h1-3,5H,4,11H2

(5-chloro-1-benzothiophen-3-yl)methanamine - Physico-chemical Properties

Molecular Formula	C9H8ClNS
Molar Mass	197.68
Density	1.363±0.06 g/cm3 (20 ºC 760 Torr)
Boling Point	160-162°C 2mm
Flash Point	158.7°C
Vapor Presure	9.58E-05mmHg at 25°C
pKa	9.18±0.29(Predicted)
Storage Condition	2-8°C
Refractive Index	1.696

(5-chloro-1-benzothiophen-3-yl)methanamine - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	34 - Causes burns
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
UN IDs	2735
Hazard Note	Irritant

(5-chloro-1-benzothiophen-3-yl)methanamine - Introduction

methylamine is an organic compound known as CBTM. Its chemical structure contains a benzothiophene ring, in which the 1 and 3 positions are connected to the methyl and amino groups, respectively. The following are some of the properties, uses and methods of preparation of the compound and related safety information:

Nature:
-Appearance: CBTM is solid, common is light yellow crystal.
-Solubility: It is soluble in some organic solvents, such as dichloromethane, methanol, etc.
-Melting point: The melting point of CBTM is generally between 80-85 degrees Celsius.
-Molecular weight: Its molecular weight is about 231.68g/mol.

Use:
-Pharmaceutical research: CBTM is an important organic synthesis intermediate that can be used to synthesize biologically active compounds, especially in the field of pharmaceutical research.
-Photoelectric materials: CBTM is also used as a lead compound for optoelectronic materials, with potential applications in organic optoelectronic devices, fluorescent dyes and other fields.

Preparation Method:
A common synthesis method is as follows:
1. First, 1-benzothiophene methanol and 2/2.5 times of thionyl chloride (as solvent) were added into the reaction flask.
2. Then, stirring at low temperature, slowly add 2.5 times the amount of ammonium sulfate.
3. This mixture will be heated to about 80 degrees Celsius and stirred for 2-3 hours.
4. Finally, the product was washed with thionyl chloride to obtain the target product CBTM.

Safety Information:
CBTM specific security measures need to be evaluated on a case-by-case basis. Generally speaking, personal protective equipment should be worn during operation to avoid direct contact with skin and eyes. When handling this compound, it should be operated in a well-ventilated environment to ensure safety. Clean up any spilled or spilled material in a timely manner and follow relevant chemical waste disposal regulations. Local safety regulations and standards should be observed when using or storing CBTM.

Last Update：2024-04-09 21:01:54