(5-methoxy-1H-indol-3-yl)acetonitrile

(5-methoxy-1H-indol-3-yl)acetonitrile - Names and Identifiers

Name	5-Methoxy-3-indolylacetonitrile
Synonyms	5-Methoxyindole-3-acetonitrile 5-METHOXYINDOLE-3-ACETONITRILE 5-METHOXY-3-INDOLYLACETONITRILE 3-(Cyanomethyl)-5-methoxyindole 5-Methoxy-3-indolylacetonitrile 3-(Cyanomethyl)-5-methoxy-1H-indole 5-Methoxy indol - 3 -yl Acetonitrile (5-METHOXY-1H-INDOL-3-YL)ACETONITRILE (5-methoxy-1H-indol-3-yl)acetonitrile 2-(5-Methoxy-1H-indol-3-yl)acetonitrile
CAS	2436-17-1
InChI	InChI=1/C11H10N2O/c1-14-9-2-3-11-10(6-9)8(4-5-12)7-13-11/h2-3,6-7,13H,4H2,1H3

(5-methoxy-1H-indol-3-yl)acetonitrile - Physico-chemical Properties

Molecular Formula	C11H10N2O
Molar Mass	186.21
Density	1.224±0.06 g/cm3(Predicted)
Melting Point	65-69 °C (lit.)
Boling Point	175-177 °C(Press: 0.01 Torr)
Flash Point	200.7°C
Solubility	Chloroform (Slightly), Methanol (Slightly)
Vapor Presure	7.09E-07mmHg at 25°C
Appearance	Solid
Color	Very Dark Brown
pKa	16.02±0.30(Predicted)
Storage Condition	-20°C Freezer
Refractive Index	1.638

(5-methoxy-1H-indol-3-yl)acetonitrile - Risk and Safety

Hazard Symbols	Xi - Irritant
WGK Germany	3
Hazard Class	IRRITANT

(5-methoxy-1H-indol-3-yl)acetonitrile - Introduction

It is an organic compound with the molecular formula C12H10N2O. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: White or light yellow crystalline solid.
-Melting point: About 111-113 ℃.
-Solubility: It has good solubility in polar organic solvents (such as ethanol, dimethylformamide).

Use:
-Chemical research: It is an important intermediate for the synthesis of indole alkaloids (such as teridine), and has a wide range of applications in the research of drugs and pesticides.
-Synthesis: It can be used to synthesize biologically active compounds, such as antibiotics, photosensitizers, etc.

Method:
The preparation method can be carried out by the following steps:
1.5-methoxyindole (5-Methoxyindole) and Bromoacetonitrile (bromoacetonitril) react to obtain fluorobromide (bromide).
2. Debromination reaction is carried out with alkali agent such as sodium hydroxide under alkaline conditions to obtain phenol.

Safety Information:
-must be unstable under normal operating conditions and should be stored in an airtight container away from direct sunlight.
-Wear appropriate personal protective equipment, such as safety glasses and gloves, during operation and use.
-Avoid skin and eye contact. If discomfort occurs after contact, rinse immediately with plenty of water and seek medical examination.

Please note that the preparation and use of chemicals should be carried out under the guidance of professionals and follow relevant safety procedures.

Last Update：2024-04-09 15:17:56