(E)-1-(6-methoxynaphthalen-2-yl)-3-pyridin-3-ylprop-2-en-1-one
DMU2139
CAS: 1821143-80-9
Molecular Formula: C19H15NO2
(E)-1-(6-methoxynaphthalen-2-yl)-3-pyridin-3-ylprop-2-en-1-one - Names and Identifiers
(E)-1-(6-methoxynaphthalen-2-yl)-3-pyridin-3-ylprop-2-en-1-one - Physico-chemical Properties
| Molecular Formula | C19H15NO2 |
| Molar Mass | 289.33 |
| Density | 1.199±0.06 g/cm3(Predicted) |
| Boling Point | 488.6±45.0 °C(Predicted) |
| pKa | 3.80±0.11(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| In vitro study | DMU2139 (6j) shows 88 and 133-fold selectivity for CYP1B1 over CYP1A1 and CYP1A2. In the presence of DMU2139, the EC 50 is reversed back to 8.3 μM from 61 μM (seen in CYP1B1-expressing cells without any inhibitor). The EC 50 value, in the presence of DMU2139, resembles the EC 50 of cisplatin, 8.7μM, in cells transfected with the empty plasmid which has no CYP1B1 gene and therefore cannot express CYP1B1 protein. |
(E)-1-(6-methoxynaphthalen-2-yl)-3-pyridin-3-ylprop-2-en-1-one - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.456 ml | 17.281 ml | 34.563 ml |
| 5 mM | 0.691 ml | 3.456 ml | 6.913 ml |
| 10 mM | 0.346 ml | 1.728 ml | 3.456 ml |
| 5 mM | 0.069 ml | 0.346 ml | 0.691 ml |
Last Update：2024-01-02 23:10:35
(E)-1-(6-methoxynaphthalen-2-yl)-3-pyridin-3-ylprop-2-en-1-one - Reference Information
| biological activity | DMU2139 is a potent and specific inhibitor of cytochrome P4501B1 (CYP1B1), the IC50 values for CYP1B1 and CYP1A1 were 9 nM and 795 nM, respectively. |
Last Update：2024-04-09 15:16:56
