(E)-3-(4-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide
(E)-3-(4-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide
CAS: 852475-26-4
Molecular Formula: C17H15FN2O3
(E)-3-(4-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide - Names and Identifiers
(E)-3-(4-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide - Physico-chemical Properties
| Molecular Formula | C17H15FN2O3 |
| Molar Mass | 314.31 |
| Solubility | DMSO: ≥10mg/mL |
| Appearance | powder |
| Color | orange |
| Storage Condition | 2-8°C |
| Use | MC1568 |
| In vitro study | MC1568 is a type II selective histone deacetylase (IIa) inhibitor with an IC50 of 220 nM and is 176 times more selective than type I. MC1568 acts on human breast cancer ZR-75.1 cell lysates and does not inhibit HDAC1, but inhibits hdac4. MC1568 (20 μm) acts on MCF-7 cells to enhance the accumulation of acetylated H3 and H4 histones, and the level of acetyl tubulin, indicating that MC1568 can inhibit hdac6. MC1568 (5 μm) acts on C2C12 cells to prevent myogenesis by decreasing the expression of myocyte enhancer factor 2D (MEF2D), stabilizing the HDAC4-HDAC3-MEF2D complex, and inhibiting differentiation-induced MEF2D acetylation. MC1568 (5 or 10 μm) interferes with RAR-and PPARγ-regulated differentiation-inducing signaling pathways. MC1568 acts on F9 cells. MC1568 specifically inhibits endoembryonic differentiation and does not affect the maturation of VA-induced promyelocytic NB4 cells. MC1568 acts on 3T3-L1 cells to reduce PPAR γ-induced lipogenesis. |
| In vivo study | MC1568 at a dose of 50 mg/kg significantly inhibited tissue-selective HDAC in mice. MC1568 acts on skeletal muscle and heart, inhibits the activity of HDAC4 and HDAC5, does not affect the activity of HDAC3, so the MEF2-HDAC complex is in an inactive state. MC1568 at a dose of 50 mg/kg has been reported to impair PPAR gamma signaling in PPRE-Luc mice, primarily at cardiac and adipose tissue sites. In a recent study of pancreatic transplantation, MC1568 enhanced endocrine beta and Delta-cells and also enhanced the expression of Pax4, a key factor required for beta and Delta cell differentiation. |
(E)-3-(4-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
(E)-3-(4-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.182 ml | 15.908 ml | 31.816 ml |
| 5 mM | 0.636 ml | 3.182 ml | 6.363 ml |
| 10 mM | 0.318 ml | 1.591 ml | 3.182 ml |
| 5 mM | 0.064 ml | 0.318 ml | 0.636 ml |
Last Update：2024-01-02 23:10:35
(E)-3-(4-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide - Reference Information
| biological activity | MC1568 is a selective HDAC inhibitor with an IC50 of 100 nM for HDAC1A, the selectivity was 34-fold higher for HDAC1A than for HDAC1B. |
| characteristics | MC1568 is a novel HDAC selective inhibitor. |
Last Update：2024-04-09 21:54:55
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Product Name: (E)-3-(4-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide Visit Supplier Webpage Request for quotationCAS: 852475-26-4
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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