Molecular Formula | C15H22N2O2 |
Molar Mass | 262.34738 |
Density | 1.02±0.1 g/cm3(Predicted) |
Boling Point | 398.7±37.0 °C(Predicted) |
Solubility | DMSO |
pKa | 11.41±0.10(Predicted) |
Storage Condition | -20℃ |
In vivo study | The purpose of the present study is to explore the pharmacological significance of Alprenoxime peripheral /βblocking activity in a non-rodent animal model. Interspecies scaling considerations predict that the doses selected in this study (1 and 5 mg/kg) are pharmacologically comparable or greater than doses used in rodent studies (2 and 6 mg/kg). More importantly, the prolonged ocular antihypertensive effects that are shown with 1% ophthalmic solutions indicate that the i.v. dose tested in the present study is likely to be more than two orders of magnitude greater than probable therapeutic doses. |