(R)-(-)-Rolipram

Name	(R)-(-)-Rolipram
Synonyms	(R)-(-)-ROLIPRAM (S)-(+)-ROLIPRAM (R)-(-)-Rolipram Rolipram (R)-(-)- (4R)-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE (4R)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE (4R)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidine-2-one
CAS	85416-75-7

Molecular Formula	C16H21NO3
Molar Mass	275.34
Density	1.155±0.06 g/cm3(Predicted)
Melting Point	132.0 to 136.0 °C
Boling Point	472.7±45.0 °C(Predicted)
Solubility	DMSO (Slightly), Methanol (Slightly)
Appearance	White to off-white solid.
Color	Off-White
pKa	16.02±0.40(Predicted)
Storage Condition	Sealed in dry,Store in freezer, under -20°C
MDL	MFCD03093861
In vitro study	The increase of cAMP synthesis with the adenylate cyclase activator forskolin or the decrease of cAMP hydrolysis by the phosphodiesterase inhibitors Isobutylmethylxanthine (IBMX) and (R)-(-)-Rolipram (MedChem Express) suppresses caspase-1 cleavage and IL-1β secretion in a dose-dependent manner.