(R)-1-BOC-3-PIPERIDINOL
(R)-1-Boc-3-hydroxypiperidine
CAS: 143900-43-0
Molecular Formula: C10H19NO3
(R)-1-BOC-3-PIPERIDINOL - Names and Identifiers
| Name | (R)-1-Boc-3-hydroxypiperidine |
| Synonyms | (R)-1-BOC-3-PIPERIDINOL (R)-1-Boc-3-hydroxypiperidine (R)-1-BOC-3-HYDROXYPIPERIDINE (R)-1-N-BOC-3-HYDROXYPIPERIDINE Tert-Butyl 3-Hydroxypiperidine-1-Carboxylate R-3-HYDROXY-1-(TERT-BUTOXYCARBONYL)PIPERIDINE Tert-Butyl (3R)-3-Hydroxypiperidine-1-Carboxylate tert- butyl (R)-3-hydroxy piperidine-1-carboxylate 1-Piperidinecarboxylic Acid, 3-Hydroxy-, 1,1-Dimethylethyl Ester, (3R)- tert-Butyl (3R)-3-hydroxypiperidine-1-carboxylate, (3R)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine |
| CAS | 143900-43-0 |
| InChI | InChI=1/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3/t8-/m1/s1 |
| InChIKey | UIJXHKXIOCDSEB-MRVPVSSYSA-N |
(R)-1-BOC-3-PIPERIDINOL - Physico-chemical Properties
| Molecular Formula | C10H19NO3 |
| Molar Mass | 201.26 |
| Density | 1.107±0.06 g/cm3(Predicted) |
| Melting Point | 43-50 °C |
| Boling Point | 292.3±33.0 °C(Predicted) |
| Flash Point | 104°C |
| Solubility | soluble in Methanol |
| Vapor Presure | 0.000198mmHg at 25°C |
| Appearance | Low Melting Solid |
| Color | White to tan |
| pKa | 14.74±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.495 |
(R)-1-BOC-3-PIPERIDINOL - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. R25 - Toxic if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Class | 6.1 |
| Packing Group | Ⅲ |
(R)-1-BOC-3-PIPERIDINOL - Reference Information
| introduction | (R)-1-Boc-3-hydroxypiperidine has a melting point of 43-50°C, a boiling point of 292.3±33.0°C(Predicted), a density of 1.107±0.06g/cm3, a flash point of 104°C, and an acidity coefficient (pKa) of 14.74±0.20(Predicted). It can be used as a pharmaceutical intermediate. |
| application | (R)-1-Boc-3-hydroxypiperidine is an important drug intermediate, which is used in the fields of lowering blood pressure, anti-swelling and anti-coccidiosis. |
| synthesis method | the suspension of (3R)-piperidine -3-alcohol hydrochloride (3.17g, 0.023 mol) in CH2Cl2(40 ml) is treated with Na2CO3(5.13g, 0 0.048 mol) dissolved in H2O(80 ml), then it was treated with diiron dicarbonate/fluorobutyl ester (5.53g, 0.025 mol) and additional CH2Cl3(24 ml). Stir the resulting mixture for 21 hours. The layers were separated and the aqueous phase was extracted with CH2Cl2(3x50 mL). The combined organic layers were dried with Na2SO4, filtered, and concentrated in vacuum. The residue was purified by column chromatography (9:1 CH2Cl2:MeOH) to obtain colorless oily (R)-1-Boc-3-hydroxypiperidine (5.07g, quantitative). Mass spectrometry (M 1):202.0. 1H nuclear magnetic resonance (400MHz, chloroform-D)δ ppm is 1.40-1.56(M,2 h),1.44(s,9h),1.67-1.80(M,1H), 1.80-1.93(M,1 H), 2.95-3.22(M,2 h), 3.47(D,J = 5.1Hz,1H),3.51(brs,1H) and 3.64-3.78(M,2 H). |
Last Update：2024-04-09 21:01:54
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