(R)-1-Methyl-3-hydroxyMethyl-pyrrolidine

(R)-1-Methyl-3-hydroxyMethyl-pyrrolidine - Names and Identifiers

Name	(R)-(1-methylpyrrolidin-3-yl)methanol
Synonyms	(R)-(1-methyL (3R)-1-Methyl-3-PyrrolidineMethanol (R)-(1-methylpyrrolidin-3-yl)methanol (R)-(1-Methylpyrrolidin-3-yl)Methanol [(3R)-1-methylpyrrolidin-3-yl]methanol 3-Pyrrolidinemethanol, 1-methyl-, (3R)- (R)-1-Methyl-3-hydroxyMethyl-pyrrolidine (R)-3-(HYDOXYMETHYL)-1-METHYLPYRROLIDINE (R)-3-(Hydroxymethyl)-1-methylpyrrolidine
CAS	1210935-33-3

(R)-1-Methyl-3-hydroxyMethyl-pyrrolidine - Physico-chemical Properties

Molecular Formula	C6H13NO
Molar Mass	115.17
Density	0.973±0.06 g/cm3(Predicted)
Boling Point	141.7±13.0 °C(Predicted)
Solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Appearance	Oil
Color	Clear Pale Yellow
pKa	14.93±0.10(Predicted)
Storage Condition	2-8°C

(R)-1-Methyl-3-hydroxyMethyl-pyrrolidine - Introduction

(R)-(-) methanol, also known as (R)-(-) methanol, is an organic compound. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: Colorless to light yellow liquid
-Formula: C≡H≡NO
-Molecular weight: 115.17g/mol
-Melting point:-60 ℃
-boiling point: 186-188 ℃
-Density: 0.950g/cm³
-Solubility: Soluble in water and most organic solvents

Use:
(R)-(-) methanol are commonly used as chiral inducers, catalysts, or solvents in organic synthesis. It can be used to synthesize a variety of drugs, pharmaceutical intermediates and natural products, such as aminophylline, phenytoin sodium, tricyclic antidepressants, etc.

Preparation Method:
(R)-(-) methanol can be synthesized by the following steps:
1. reacting (R)-(1-methylpyrrol-3-yl) methylamine with an oxidizing agent (such as peracetic acid or tert-butyl sodium hydroxide) to obtain the corresponding aldehyde;
2. The aldehyde reacts with hydrogen and a platinum catalyst (such as platinum hydroxide) to reduce (R)-(r) methanol.

Safety Information:
(R)-() methanol is generally safe under correct use and storage, but the following matters still need to be paid attention:
-Avoid contact with strong oxidants to avoid fire or explosion.
-In operation, should use appropriate protective measures, such as wearing gloves and safety glasses.
-Avoid direct contact with skin and eyes. In case of accidental contact, rinse immediately with plenty of water.
-Use in a well-ventilated place to avoid inhaling steam or mist. If necessary, wear respiratory protection.
-Storage should be sealed and kept away from fire and heat sources.

Last Update：2024-04-09 19:05:53