(R)-1-溴-4-(1-异氰酸基乙基)苯

(R)-1-溴-4-(1-异氰酸基乙基)苯 - Names and Identifiers

Name	(R)-(+)-1-(4-Bromophenyl)ethyl isocyanate
Synonyms	(R)-(+)-(4-BROMOPHENYL)ETHYL ISOCYANATE (R)-1-Bromo-4-(1-isocyanatoethyl)benzene (R)-(+)-1-(4-BROMOPHENYL)ETHYL ISOCYANATE 1-bromo-4-[(1R)-1-isocyanatoethyl]benzene (R)-(+)-1-(4-Bromophenyl)Ethyl Isocyanate (R)-(+)-1-(4-Bromophenyl)ethyl isocyanate 1-Bromo-4-[(1R)-1-isocyanatoethyl]benzene benzene, 1-bromo-4-[(1R)-1-isocyanatoethyl]- Benzene, 1-bromo-4-[(1R)-1-isocyanatoethyl]-
CAS	618461-78-2
EINECS	000-000-0
InChI	InChI=1/C9H8BrNO/c1-7(11-6-12)8-2-4-9(10)5-3-8/h2-5,7H,1H3/t7-/m1/s1

(R)-1-溴-4-(1-异氰酸基乙基)苯 - Physico-chemical Properties

Molecular Formula	C9H8BrNO
Molar Mass	226.07
Density	1.39g/cm³
Melting Point	30-32°C
Boling Point	145-147°C 7mm
Flash Point	145-147°C/7mm
Vapor Presure	0.00483mmHg at 25°C
BRN	7869672
Sensitive	Moisture Sensitive
Refractive Index	1.562

(R)-1-溴-4-(1-异氰酸基乙基)苯 - Risk and Safety

Risk Codes	R20/22 - Harmful by inhalation and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S23 - Do not breathe vapour. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
UN IDs	2206
Hazard Class	6.1
Packing Group	III

(R)-1-溴-4-(1-异氰酸基乙基)苯 - Introduction

(R)-( )-1-(4-bromophenyl) ethyl isocyanate is an organic compound with the chemical formula C10H8BrNO2. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: colorless liquid
-Boiling point: about 220-225 degrees Celsius
-Melting point: about -10 degrees Celsius
-Density: about 1.46g/cm³
-Molecular weight: about 262.08g/mol
-Soluble: Soluble in organic solvents such as dimethylformamide (DMF) and dichloromethane

Use:
(R)-( )-1-(4-bromophenyl) ethyl isocyanate can be used in a variety of reactions in organic synthesis, especially as a chiral reagent and intermediate in the synthesis of chiral drugs. It can be used in the synthesis of chiral organic compounds, such as chiral ketones, chiral alcohols and chiral ethers. It can also be used as a reagent for transesterification reactions.

Preparation Method:
The preparation method of the compound can be carried out by the following steps:
1.1-bromo -4-toluene and alcohol reaction, generating 1-bromo -4-methyl phenyl ethanol.
2. 1-bromo-4-methylphenylethanol reacts with methyl isocyanate under alkaline conditions to generate (R)-( )-1-(4-bromophenyl) ethyl isocyanate.

Safety Information:
(R)-( )-1-(4-Bromophenyl) ethyl isocyanate is a potentially dangerous compound. The following items should be paid attention to when using:
-The compound is irritating and toxic, and may cause damage to the eyes, respiratory system and skin.
-Wear appropriate protective equipment such as gloves, goggles and protective clothing when using.
-Avoid contact with strong oxidants and other combustibles during use and storage.
-Operate in a well-ventilated place and avoid inhaling its vapors.
-In case of contact or inhalation, wash or seek medical attention immediately.

Please ensure that you have relevant safety knowledge and laboratory skills before using this compound, and follow laboratory safety guidelines.

Last Update：2024-04-09 02:00:47