(R)-2-hydroxy-N,N-dimethyl-3-(2-(1-(5-methylfuran-2-yl)propylamino)-3

Name	SCH 527123
Synonyms	Sch 527123 SCH 527123 SCH527123, Navarixin (R)-2-hydroxy-N,N-dimethyl-3-(2-(1-(5-methylfuran-2-yl)propylamino)-3 2-Hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl (R)-2-hydroxy-N,N-dimethyl-3-(2-(1-(5-methylfuran-2-yl)propylamino)-3,4-dioxocyclobut-1-enylamino)benzamide (R)-2-hydroxy-N,N-diMethyl-3-((2-((1-(5-Methylfuran-2-yl)propyl)aMino)-3,4-dioxocyclobut-1-en-1-yl)aMino)benzaMide Benzamide, 2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]- 3-[[3-[(Dimethylamino)carbonyl]-2-hydroxyphenyl]amino]-4-[[(R)-1-(5-methylfuran-2-yl)propyl]amino]cyclobut-3-ene-1,2-dione
CAS	473727-83-2

Last Update：2024-01-02 23:10:35

Overview	3-[[3-[(dimethylamino) carbonyl]-2-hydroxyphenyl] amino]-4-[[(R)-1-(5-methylfuran-2-yl) propyl] amino] -3-cyclobutene-1, 2-Diketone is an organic chemical substance, which is an effective allosteric antagonist of CXCR1 and CXCR2, and can only be used in scientific research experiments.
biological activity	Navarixin (SCH-527123, MK-7123, PS-291822) is an effective CXCR2/CXCR1 antagonist with oral bioavailability, IC50 is 2.6 nM and 36 nM respectively.
target	TargetValue CXCR2 (Cell-free assay) 2.6 nM CXCR1 (Cell-free assay) 36 nM
Target	Value
CXCR2 (Cell-free assay)	2.6 nM
CXCR1 (Cell-free assay)	36 nM

Last Update：2024-04-09 21:54:55

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