(R)-5-Hydroxy-2-(4-hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyMethyl)tetrahydro-2H-pyran-2-yl)oxy)chroMan-4-one
Prunin
CAS: 529-55-5
Molecular Formula: C21H22O10
(R)-5-Hydroxy-2-(4-hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyMethyl)tetrahydro-2H-pyran-2-yl)oxy)chroMan-4-one - Names and Identifiers
(R)-5-Hydroxy-2-(4-hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyMethyl)tetrahydro-2H-pyran-2-yl)oxy)chroMan-4-one - Physico-chemical Properties
| Molecular Formula | C21H22O10 |
| Molar Mass | 434.4 |
| Density | 1.597±0.06 g/cm3(Predicted) |
| Melting Point | 222-224°C |
| Boling Point | 802.4±65.0 °C(Predicted) |
| Specific Rotation(α) | -41.8 (Me2CO) |
| Solubility | Soluble in methanol, chloroform |
| pKa | 7.18±0.40(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| In vitro study | Prunin exhibited dose-dependent inhibitory activity against ONOO--mediated tyrosine nitration and stimulated glucose uptake by decreasing PTP1B expression level in insulin-resistant HepG2 cells. Prunin shows significant inhibitory activity against α-glucosidase, with an IC 50 of 317 ± 2.12 µM. |
(R)-5-Hydroxy-2-(4-hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyMethyl)tetrahydro-2H-pyran-2-yl)oxy)chroMan-4-one - Risk and Safety
| Hazard Symbols | N - Dangerous for the environment |
| Risk Codes | R22 - Harmful if swallowed R50 - Very Toxic to aquatic organisms |
| Safety Description | S22 - Do not breathe dust. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
(R)-5-Hydroxy-2-(4-hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyMethyl)tetrahydro-2H-pyran-2-yl)oxy)chroMan-4-one - Reference
| Reference Show more | 1. Wang Weina, Li Yan, Tian Jing, Fei Xu, Xu Longquan, Lian Meng. Purification and characterization of naringinase from Aspergillus niger by liquid fermentation [J]. Modern food science and technology, 2016,32(07):72-78 46. 2. Yi Zi bin, Hu Ji Zhi, Yu Yu, etc. Preparation of pulluning from α-L-rhamnosidase produced by Aspergillus niger [J]. Journal of Nanchang University (Natural Science Edition), 2017, 41(06):55-60. 3. Mi, Nan, et al. "Metabolite profiling of traditional Chinese medicine formula Dan Zhi Tablet: an integrated strategy based on UPLC-QTOF/MS combined with multivariate statistical analysis." Journal of pharmaceutical and biomedical analysis 164 (2019): 70-85 4. Yang, Zheng Zhong, et al. "Deciphering bioactive compounds of complex natural products by tandem mass spectral molecular networking combined with an aggregation-induced emission based probe." Journal of Pharmaceutical Analysis (2020).https://doi.org/10.1016/ 5. [IF=5.645] Zhang-Zhen Bai et al."Comparative investigation on metabolites and biological activities of Paeonia ostii stamens from different geographical regions of China."Ind Crop Prod. 2021 Nov;172:114038 6. [IF=4.769] Zhenzhong Yang et al."Deciphering bioactive compounds of complex natural products by tandem mass spectral molecular networking combined with an aggregation-induced emission based probe."J Pharm Anal. 2020 Nov;: 7. [IF=2.926] Li Bin-Chun et al."Target Discovery of Novel α-l-Rhamnosidases from Human Fecal Metagenome and Application for Biotransformation of Natural Flavonoid Glycosides."Appl Biochem Biotech. 2019 Dec;189(4):1245-1261 |
(R)-5-Hydroxy-2-(4-hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyMethyl)tetrahydro-2H-pyran-2-yl)oxy)chroMan-4-one - Reference Information
| Plant Source: | fructus aurantii immaturus |
| biological activity | Prunin is a potent human intestinal Virus A71 (HEVA71) inhibitor. Prunin had a strong inhibitory effect on protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 5.5 μm. |
| Use | cosmetic raw material for health products, sweetener precursor. for content determination/identification/pharmacological experiments, etc |
Last Update：2024-04-09 20:45:29
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Product Name: Prunin Visit Supplier Webpage Request for quotationCAS: 529-55-5
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Prunin Visit Supplier Webpage Request for quotationCAS: 529-55-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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