(R)-C-(1-Ethyl-pyrrolidin-2-yl)-methylamine
(R)-2-(Aminomethyl)-1-ethylpyrrolidine
CAS: 22795-97-7
Molecular Formula: C7H16N2
(R)-C-(1-Ethyl-pyrrolidin-2-yl)-methylamine - Names and Identifiers
(R)-C-(1-Ethyl-pyrrolidin-2-yl)-methylamine - Physico-chemical Properties
| Molecular Formula | C7H16N2 |
| Molar Mass | 128.22 |
| Density | 0.90 |
| Boling Point | 50-52°C(lit.) |
| Flash Point | 57°C |
| Appearance | Liquid |
| Color | Clear colorless to yellow |
| pKa | 10.04±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | Hygroscopic |
| Refractive Index | 1.4655-1.4675 |
| MDL | MFCD00671482 |
(R)-C-(1-Ethyl-pyrrolidin-2-yl)-methylamine - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S39 - Wear eye / face protection. S60 - This material and its container must be disposed of as hazardous waste. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S23 - Do not breathe vapour. |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 2 |
| HS Code | 29339900 |
| Hazard Class | 8 |
(R)-C-(1-Ethyl-pyrrolidin-2-yl)-methylamine - Introduction
(R)-2-(Aminomethyl)-1-ethylpyrrolidine is a chiral organic compound with the chemical formula C8H17N. It is a colorless to light yellow oily liquid with a pungent ammonia odor.
(R)-2-(Aminomethyl)-1-ethylpropylrolidine has a wide range of applications in the field of medicine. It can be used as a chiral intermediate for the synthesis of a variety of pharmaceutical compounds, such as antipsychotic drugs, antiepileptic drugs, folic acid antagonists and so on. In addition, it can also be used to synthesize plant growth regulators and pesticides.
There are two main methods for the preparation of (R)-2-(Aminomethyl)-1-ethylpyrrolidine. One is obtained by a reduction reaction of ketone aldehyde, and the specific step is to add 2-pyrrole formaldehyde and 1-ethyl borate to the presence of a hydrogen catalyst (such as Pd/C) for reduction; the other is obtained by an amide synthesis method, and the specific step is to react 2-pyrrole formaldehyde with 1-ethyl amine under acidic conditions.
Regarding safety information,(R)-2-(Aminomethyl)-1-ethylpyrrolidine is irritating to the skin, eyes and respiratory tract, and direct contact should be avoided. At the same time, wear appropriate personal protective equipment, such as protective gloves, goggles and protective masks. Pay attention to good ventilation during operation and avoid inhalation or contact with excessive compounds.
(R)-2-(Aminomethyl)-1-ethylpropylrolidine has a wide range of applications in the field of medicine. It can be used as a chiral intermediate for the synthesis of a variety of pharmaceutical compounds, such as antipsychotic drugs, antiepileptic drugs, folic acid antagonists and so on. In addition, it can also be used to synthesize plant growth regulators and pesticides.
There are two main methods for the preparation of (R)-2-(Aminomethyl)-1-ethylpyrrolidine. One is obtained by a reduction reaction of ketone aldehyde, and the specific step is to add 2-pyrrole formaldehyde and 1-ethyl borate to the presence of a hydrogen catalyst (such as Pd/C) for reduction; the other is obtained by an amide synthesis method, and the specific step is to react 2-pyrrole formaldehyde with 1-ethyl amine under acidic conditions.
Regarding safety information,(R)-2-(Aminomethyl)-1-ethylpyrrolidine is irritating to the skin, eyes and respiratory tract, and direct contact should be avoided. At the same time, wear appropriate personal protective equipment, such as protective gloves, goggles and protective masks. Pay attention to good ventilation during operation and avoid inhalation or contact with excessive compounds.
Last Update：2024-04-09 21:11:58
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