(R)-N,N-Dimethyl-1-(pyrrolidin-2-yl)methanamine

(R)-N,N-Dimethyl-1-(pyrrolidin-2-yl)methanamine - Names and Identifiers

Name	(R)-2-(Dimethylaminomethyl)pyrrolidine 2HCl
Synonyms	-N,N-Dimethyl-1-(pyrrolidin-2-yl) (R)-2-(DiMethylaMino)Methylpyrrolidine dimethyl[(2R)-pyrrolidin-2-ylmethyl]amine (R)-2-(DiMethylaMinoMethyl)pyrrolidine 2HCl (R)-2-(Dimethylaminomethyl)pyrrolidine 2HCl N,N-dimethyl((R)-pyrrolidin-2-yl)methanamine 2-Pyrrolidinemethanamine, N,N-dimethyl-, (2R)- (R)-N,N-Dimethyl-1-(pyrrolidin-2-yl)methanamine (R)-2-(Dimethylaminomethyl)pyrrolidine Dihydrochloride
CAS	1166842-56-3

(R)-N,N-Dimethyl-1-(pyrrolidin-2-yl)methanamine - Physico-chemical Properties

Molecular Formula	C7H16N2
Molar Mass	128.22
Storage Condition	2-8°C(protect from light)

(R)-N,N-Dimethyl-1-(pyrrolidin-2-yl)methanamine - Reference Information

application

(R)-2-(dimethylaminomethyl) pyrrolidine hydrochloride can be used as an intermediate in organic synthesis and pharmaceutical intermediates, mainly used in laboratory research and development process and chemical production process.

preparation

take 1g of N,N-dimethyl -5-oxo -2-pyrrolidine formamide and 0.92g of sodium borohydride, put them into a 100mL four-mouth bottle, cool down in an ice salt bath, add 30mL of tetrahydrofuran, add nitrogen protection, add 2.08g of iodine tetrahydrofuran solution dropwise, and heat up and reflux after completion. Thin layer chromatography detects the progress of the reaction. After the reaction is over, stop heating, turn the system into an ice bath, add water to destroy the sodium borohydride that did not participate in the reaction, filter, extract the filtrate with ethyl acetate, merge ethyl acetate, and saturate Sodium chloride washes the organic layer, dry and spin to obtain a white solid, namely (S)-1-benzyl -3, 4-dihydroxypyrrolidine-borane complex. Dissolve the white solid in methanol and reflux for 8h, spin dry, add 10mL of ethyl acetate and 10mL of dilute hydrochloric acid (0.1N), separate the water layer, neutralize sodium hydroxide to pH 8, extract the product from ethyl acetate, concentrate under reduced pressure to obtain oily liquid, and recrystallize with acetone to obtain gray-white solid (R)-2-(dimethylaminomethyl) pyrrolidine hydrochloride.

Last Update：2024-04-09 20:45:29