(R)-N-(tert-butoxycarbonyl)pyroglutaMate

(R)-N-(tert-butoxycarbonyl)pyroglutaMate - Names and Identifiers

Name	Boc-D-pyroglutamic acid methyl ester
Synonyms	1-Boc-5-oxo-D-proline Methyl ester Boc-D-Pyroglutamic acid methyl ester Boc-L-pyroglutamic acid methyl ester Boc-D-pyroglutamic acid methyl ester (R)-N-(tert-butoxycarbonyl)pyroglutaMate (R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE Methyl(R)-N-(tert-butoxycarbonyl)pyroglutamate METHYL (R)-N-(TERT-BUTOXYCARBONYL)PYROGLUTAMATE (R)-1-Tert-butyl2-Methyl5-oxopyrrolidine-1,2-dicarboxylate (R)-5-OXO-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER 1,2-Pyrrolidinedicarboxylicacid, 5-oxo-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R)- 1,2-Pyrrolidinedicarboxylicacid, 5-oxo-, 1-(1,1-dimethylethyl) 2-methyl ester, (R)-
CAS	128811-48-3
InChI	InChI=1/C11H17NO5/c1-10(2,3)17-9(16)12-7(13)5-6-11(12,4)8(14)15/h5-6H2,1-4H3,(H,14,15)/t11-/m1/s1

(R)-N-(tert-butoxycarbonyl)pyroglutaMate - Physico-chemical Properties

Molecular Formula	C11H17NO5
Molar Mass	243.26
Density	1.209
Melting Point	68-69℃
Boling Point	361.6±35.0 °C(Predicted)
Appearance	White crystal
pKa	-4.28±0.40(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.506
MDL	MFCD07783728

(R)-N-(tert-butoxycarbonyl)pyroglutaMate - Introduction

Boc-D-pyroglutamic acid methyl ester is an organic compound with the following properties:

1. Appearance: Boc-D-methyl pyroglutamate is a white crystalline solid.
2. molecular formula: C15H23NO6
3. Molecular weight: 309.35g/mol

The main purpose of Boc-D-pyroglutamic acid methyl ester is to be introduced into amino acid molecules as a protecting group (Boc group) for organic synthesis reactions. By reacting Boc-D-pyroglutamate methyl ester with other compounds, a compound having a specific function, such as a drug, a peptide, a protein, or the like, can be synthesized.

Preparation of Boc-D-pyroglutamic acid methyl ester is usually obtained by reacting pyroglutamic acid methyl ester with Boc acid chloride under basic conditions. The reaction is usually carried out at low temperature and requires a suitable solvent such as dimethylformamide (DMF) or dichloromethane and the like.

Regarding safety information, Boc-D-methyl pyroglutamate is toxic and irritant and may cause discomfort or irritation in contact with skin, eyes and mucous membranes. Appropriate protective measures should be taken during operation, such as wearing protective glasses, gloves and laboratory coats. At the same time, it should be operated in a well-ventilated area to avoid inhaling its vapor. If exposed or inhaled, rinse immediately with clean water and seek medical help.

Last Update：2024-04-09 20:02:46