(R)-N-Methyl-alpha,alpha-diphenylpyrrolidinemethanol

(R)-N-Methyl-alpha,alpha-diphenylpyrrolidinemethanol - Names and Identifiers

Name	(R)-Alpha,Alpha-Diphenylmethylprolinol
Synonyms	(2R)-(-)-N-Methyl-α α,α-Diphenyl-N-methyl-D-prolinol (R)-Alpha,Alpha-Diphenylmethylprolinol alpha,alpha-Diphenyl-N-methyl-D-prolinol [(2R)-1-methylpyrrolidin-2-yl]-diphenylmethanol [(2R)-1-methylpyrrolidin-2-yl](diphenyl)methanol 1,1,1-Diphenyl-(n-methyl-pyrroline-2yl)-methanol (2R)-N-Methyl-α,α-diphenyl-2-pyrrolidinemethanol (R)-N-Methyl-alpha,alpha-diphenylpyrrolidinemethanol (2R)-2-[hydroxy(diphenyl)methyl]-1-methylpyrrolidinium (R)-(-)-2-[Hydroxy(diphenyl)methyl]-1-methylpyrrolidine (R)-alpha,alpha-Diphenyl-N-methyl-2-pyrrolidinemethanol (2R)-(-)-2-[Diphenyl(hydroxy)methyl]-1-methylpyrrolidine, (-)-alpha,alpha-Diphenyl-N-methyl-D-prolinol
CAS	144119-12-0
EINECS	635-081-7
InChI	InChI=1/C18H21NO/c1-19-14-8-13-17(19)18(20,15-9-4-2-5-10-15)16-11-6-3-7-12-16/h2-7,9-12,17,20H,8,13-14H2,1H3/p+1/t17-/m1/s1

(R)-N-Methyl-alpha,alpha-diphenylpyrrolidinemethanol - Physico-chemical Properties

Molecular Formula	C18H21NO
Molar Mass	267.37
Density	1.116±0.06 g/cm3(Predicted)
Melting Point	68-71°C
Boling Point	406.8±25.0 °C(Predicted)
Specific Rotation(α)	-52° (c=1, CHCl3)
Flash Point	196.8°C
Vapor Presure	2.39E-07mmHg at 25°C
Appearance	White to off-white crystalline powder
Color	white to light-yellow
BRN	1535407
pKa	13.15±0.29(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	-55 ° (C=1, CHCl3)
MDL	MFCD00145217

(R)-N-Methyl-alpha,alpha-diphenylpyrrolidinemethanol - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
FLUKA BRAND F CODES	10-34
HS Code	29339900

(R)-N-Methyl-alpha,alpha-diphenylpyrrolidinemethanol - Introduction

(R)-Alpha,Alpha-Diphenylmethylprolinol, also known as prolinol amphetamine, is an organic compound. It is a chiral compound, there are two stereoisomers, respectively, the optical activity of D and L.

(R)-Alpha,Alpha-Diphenylmethylprolinol are mainly used as over-the-counter drugs and food additives. As a drug, it has antitussive, antipyretic and vasoconstrictor effects. Common drug products include cold medicine, weight loss medicine and cough medicine. As a food additive, it can be used to increase the flavor of food, enhance appetite and promote digestion.

According to the preparation method,(R)-Alpha,Alpha-Diphenylmethylprolinol is usually obtained by an exhaust gas phase reaction of phenylacetone and benzaldehyde. Specific reaction conditions and catalysts may vary, and aldehyde reducing agents or hydrogenation catalysts are generally used.

Regarding safety information, it should be noted that prolinol amphetamine has been banned or restricted in some countries because of its association with the occurrence of some cardiovascular diseases. When using drugs or food additives, follow the product instructions and recommended dosages. In addition, prolinol amphetamine may have certain pharmacological activities and side effects, such as causing mental excitement, increasing blood pressure and heart rate, so excessive use should be avoided. If there are any unpleasant reactions or unclear problems, it is recommended to consult the advice of a doctor or professional.

Last Update：2024-04-09 20:52:54