(R,R)-(+)-2,2-Isopropylidenebis(4-Tert-Butyl-2-Oxazoline)

(R,R)-(+)-2,2-Isopropylidenebis(4-Tert-Butyl-2-Oxazoline) - Names and Identifiers

Name	(R,R)-(-)-2,2'-Isopropylidenebis(4-Tert-Butyl-2-Oxazoline)
Synonyms	(R,R)-(-)-2,2'-ISOPROPYLIDENEBOXAZOLINE) (R,R)-(+)-2,2-Isopropylidenebis(4-Tert-Butyl-2-Oxazolin (R,R)-(+)-2,2-Isopropylidenebis(4-Tert-Butyl-2-Oxazoline) (R,R)-(-)-2,2'-Isopropylidenebis(4-Tert-Butyl-2-Oxazoline) (R,R)-(-)-2,2'-ISOPROPYLIDENEBIS(4-TERT-BUTYL-2-OXAZOLINE) (4R,4'R)-2,2'-(Propane-2,2-diyl)bis(4-(tert-butyl)-4,5-dihydrooxazole) (4R,4'R)-2,2'-propane-2,2-diylbis(4-tert-butyl-4,5-dihydro-1,3-oxazole) (4R,4'R)- 2,2'-(1-Methylethylidene)bis[4-(1,1-diMethylethyl)-4,5-dihydro-Oxazole (4R)-4-tert-butyl-2-{2-[(4R)-4-tert-butyl-4,5-dihydro-1,3-oxazol-2-yl]propan-2-yl}-4,5-dihydro-1,3-oxazole (R,R)-(+)-2,2'-(Dimethylmethylene)bis(4-tert-butyl-2-oxazoline)(R,R)-(+)-2,2-Bis(4-tert-butyl-2-oxazolin-2-yl)propane
CAS	131833-97-1
InChI	InChI=1/C17H30N2O2/c1-15(2,3)11-9-20-13(18-11)17(7,8)14-19-12(10-21-14)16(4,5)6/h11-12H,9-10H2,1-8H3/t11-,12-/m0/s1

(R,R)-(+)-2,2-Isopropylidenebis(4-Tert-Butyl-2-Oxazoline) - Physico-chemical Properties

Molecular Formula	C17H30N2O2
Molar Mass	294.43
Density	1.04±0.1 g/cm3(Predicted)
Melting Point	88.0 to 92.0 °C
Boling Point	350.4±25.0 °C(Predicted)
Flash Point	134.912°C
Solubility	soluble in Chloroform
Vapor Presure	0mmHg at 25°C
Appearance	powder to crystal
Color	White to Almost white
pKa	5.69±0.70(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.516
MDL	MFCD07368371

(R,R)-(+)-2,2-Isopropylidenebis(4-Tert-Butyl-2-Oxazoline) - Risk and Safety

Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
HS Code	29349990

(R,R)-(+)-2,2-Isopropylidenebis(4-Tert-Butyl-2-Oxazoline) - Introduction

(R,R)-( )-2,2 '-isopropylidene bis (4-tertbutyl-2-oxazoline) is a chiral molecule with the following properties:

Appearance: colorless crystal
Molecular formula: C23H34N2O2
Molecular weight: 382.53g/mol

It is a very important chiral ligand and is widely used in catalytic asymmetric synthesis reactions. In organic synthesis, it can form chiral complexes with transition metals, which can be used to catalyze asymmetric oxidation, reduction, olefin cyclization and other reactions, and can produce high selectivity and high stereochemical reaction products.

In the preparation method, (R,R)-( )-2,2 '-isopropylidene bis (4-tert-butyl -2-oxazoline) can be synthesized through a two-step reaction. First, an isopropyl functional group is introduced at the head by an isopropylation reaction. The tert-butyl substituent is then introduced by tert-butylation. Finally, the target product is obtained by reduction. (Note that this is only a brief description of the synthesis steps, the specific reaction details and conditions may be different, so it is recommended to refer to professional literature guidance during synthesis)

This compound is relatively safe under normal circumstances, but the following matters still need to be paid attention:
-It is an organic compound with a certain degree of flammability. Contact with open flames or high temperature substances should be avoided.
-Try to avoid inhaling its dust or solution, because it may cause irritation to the respiratory tract and eyes.
-Wear appropriate personal protective equipment, such as goggles, lab coats and gloves.
-When using or storing, it should be stored in a closed container, away from heat and fire sources.

In summary,(R,R)-( )-2,2 '-isopropylidene bis (4-tert-butyl-2-oxazoline) is an important chiral ligand. It has a wide range of applications in asymmetric synthesis, but it should be used safely during operation.

Last Update：2024-04-10 22:29:15