(RS)-ALFA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID

Name	(R,S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Synonyms	AMPA (RS)-AMPA 2-AMINO-3-(3-HYDROXY-5-METHYLISOXAZOL-4-YL)PROPANOIC ACID (R,S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (R,S)-A-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID (RS)-ALFA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID (RS)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID (R,S)-2-AMINO-3-(3-HYDROXY-5-METHYL-4-ISOXAZOLYL)PROPIONIC ACID
CAS	77521-29-0

Molecular Formula	C7H10N2O4
Molar Mass	186.17
Density	1.386±0.06 g/cm3(Predicted)
Melting Point	240 °C
Solubility	H2O: 1.2mg/mL
Appearance	solid
Color	white
pKa	2.15±0.10(Predicted)
Storage Condition	2-8°C
In vitro study	(RS)-AMPA (10-3-10-4 M) causes depolarizations of cultured rat spinal and brainstem neurones. The depolarization by (RS)-AMPA is clearly dose-dependent, although there is a great variability of effects between individual neurones. Application of (RS)-AMPA at 10-5 M produces only small depolarizations (3-7 mV), whereas at 10-4 M, the amplitudes of the depolarizations ranged from 4 to 33 mV. (RS)-AMPA also causes an increase of the discharge rate of spontaneously firing neurones or sometimes evoked a short burst of action potentials in silent cells. (RS)-AMPA exerts its depolarizing effects by activating glutamate/quisqualate receptors without affecting NMDA receptors.

WGK Germany

EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
biological activity	(RS)-AMPA ((±)-AMPA) is a glutamate analog, it is a potent and selective agonist of the excitatory neurotransmitter L-glutamate (L-glutamic acid). (RS)-AMPA does not interfere with the binding site of alginic acid or NMDA receptors.

Last Update：2024-04-09 15:16:58

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