77521-29-0
(R,S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
CAS: 77521-29-0
Molecular Formula: C7H10N2O4
77521-29-0 - Names and Identifiers
77521-29-0 - Physico-chemical Properties
| Molecular Formula | C7H10N2O4 |
| Molar Mass | 186.17 |
| Density | 1.386±0.06 g/cm3(Predicted) |
| Melting Point | 240 °C |
| Solubility | H2O: 1.2mg/mL |
| Appearance | solid |
| Color | white |
| pKa | 2.15±0.10(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | (RS)-AMPA (10-3-10-4 M) causes depolarizations of cultured rat spinal and brainstem neurones. The depolarization by (RS)-AMPA is clearly dose-dependent, although there is a great variability of effects between individual neurones. Application of (RS)-AMPA at 10-5 M produces only small depolarizations (3-7 mV), whereas at 10-4 M, the amplitudes of the depolarizations ranged from 4 to 33 mV. (RS)-AMPA also causes an increase of the discharge rate of spontaneously firing neurones or sometimes evoked a short burst of action potentials in silent cells. (RS)-AMPA exerts its depolarizing effects by activating glutamate/quisqualate receptors without affecting NMDA receptors. |
77521-29-0 - Risk and Safety
| WGK Germany | 3 |
77521-29-0 - References
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| biological activity | (RS)-AMPA ((±)-AMPA) is a glutamate analog, it is a potent and selective agonist of the excitatory neurotransmitter L-glutamate (L-glutamic acid). (RS)-AMPA does not interfere with the binding site of alginic acid or NMDA receptors. |
Last Update：2024-04-09 15:16:58
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Product Name: (R,S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Visit Supplier Webpage Request for quotation
CAS: 77521-29-0
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 77521-29-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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