(S)-(-)-3-butyn-2-ol
(S)-(-)-3-butyn-2-ol
CAS: 2914-69-4
Molecular Formula: C4H6O
(S)-(-)-3-butyn-2-ol - Names and Identifiers
| Name | (S)-(-)-3-butyn-2-ol |
| Synonyms | (S)-3-Bytyn-2-ol (S)-but-3-yn-2-ol (2S)-but-3-yn-2-ol (S)-(-)3-Bytyn-2-ol (S)-(-)-1-Bytyn-3-ol (S)-(-)-3-Butyn-2-ol (S)-(-)-3-butyn-2-ol (2S)-(-)-But-3-yn-2-ol (3S)-(-)-But-1-yn-3-ol, (3S)-(-)-3-Hydroxybut-1-yne |
| CAS | 2914-69-4 |
| EINECS | 608-322-9 |
| InChI | InChI=1/C4H6O/c1-3-4(2)5/h1,4-5H,2H3/t4-/m0/s1 |
| InChIKey | GKPOMITUDGXOSB-BYPYZUCNSA-N |
(S)-(-)-3-butyn-2-ol - Physico-chemical Properties
| Molecular Formula | C4H6O |
| Molar Mass | 70.09 |
| Density | 0.883 g/mL at 20 °C (lit.) |
| Melting Point | -22.07°C (estimate) |
| Boling Point | 108-111 °C (lit.) |
| Specific Rotation(α) | -45 º (neat) |
| Flash Point | 78°F |
| Water Solubility | Miscible with water. |
| Vapor Presure | 17.3mmHg at 25°C |
| Appearance | Liquid |
| Specific Gravity | 0.88 |
| Color | Clear colorless to yellow |
| BRN | 4652597 |
| pKa | 13.28±0.20(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.426(lit.) |
(S)-(-)-3-butyn-2-ol - Risk and Safety
| Risk Codes | R11 - Highly Flammable R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed. R36/38 - Irritating to eyes and skin. R36/37/38 - Irritating to eyes, respiratory system and skin. R28 - Very Toxic if swallowed R24 - Toxic in contact with skin |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S28A - |
| UN IDs | UN 2929 6.1/PG 2 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-23 |
| HS Code | 29052900 |
| Hazard Class | 6.1 |
| Packing Group | II |
(S)-(-)-3-butyn-2-ol - Introduction
(S)-(-)-3-butyn-2-ol((S)-(-)-3-butyn-2-ol) is an organic compound with the chemical formula C4H6O. It is a colorless liquid with a distinctive smell. The compound is soluble in water and many organic solvents at normal temperature.
(S)-(-)-3-butyn-2-ol is commonly used as a chiral reagent and catalyst in organic synthesis. It can participate in a variety of reactions, such as asymmetric nucleophilic addition, asymmetric Michael addition and Suzuki coupling reaction. These reactions can be used to construct carbon-carbon bonds and carbon-oxygen bonds of chiral compounds.
The method for preparing (S)-(-)-3-butyn-2-ol is usually a relatively simple synthesis method catalyzed by sodium hydroxide and copper sulfate. The specific procedure involves recovering acetylene and O-fluorobenzaldehyde from (S)-α-methylbenzylamine and reacting them together with sodium hydroxide and copper sulfate.
For safety information,(S)-(-)-3-butyn-2-ol may be irritating to the eyes, skin and mucous membranes at high concentrations. During use and handling, wear gloves and protective glasses to avoid contact with skin and inhalation of vapors. When used in a laboratory environment, it should be placed in a well-ventilated place and properly sealed.
(S)-(-)-3-butyn-2-ol is commonly used as a chiral reagent and catalyst in organic synthesis. It can participate in a variety of reactions, such as asymmetric nucleophilic addition, asymmetric Michael addition and Suzuki coupling reaction. These reactions can be used to construct carbon-carbon bonds and carbon-oxygen bonds of chiral compounds.
The method for preparing (S)-(-)-3-butyn-2-ol is usually a relatively simple synthesis method catalyzed by sodium hydroxide and copper sulfate. The specific procedure involves recovering acetylene and O-fluorobenzaldehyde from (S)-α-methylbenzylamine and reacting them together with sodium hydroxide and copper sulfate.
For safety information,(S)-(-)-3-butyn-2-ol may be irritating to the eyes, skin and mucous membranes at high concentrations. During use and handling, wear gloves and protective glasses to avoid contact with skin and inhalation of vapors. When used in a laboratory environment, it should be placed in a well-ventilated place and properly sealed.
Last Update：2024-04-10 22:29:15
