(S)-1-(p-Chlorobenzhydryl)piperazine
1-[(S)-(4-chlorophenyl)(phenyl)methyl]piperazine
CAS: 439858-21-6
Molecular Formula: C17H19ClN2
(S)-1-(p-Chlorobenzhydryl)piperazine - Names and Identifiers
| Name | 1-[(S)-(4-chlorophenyl)(phenyl)methyl]piperazine |
| Synonyms | Meclizine Impurity 9 Cetirizine Impurity 39 Cinnarizine Impurity 22 (S)-1-(p-Chlorobenzhydryl)piperazine 1-[(S)-(4-Chlorophenyl)(phenyl)methyl]piperazine 1-[(S)-(4-chlorophenyl)(phenyl)methyl]piperazine Piperazine, 1-[(S)-(4-chlorophenyl)phenylmethyl]- Chlorophenyl)(phenyl)methyl)piperazine,(S)-1-((4- piperazine, 1-[(S)-(4-chlorophenyl)phenylmethyl]- (S)-(+)-1-[(4-Chlorophenyl)phenylmethyl]piperazine |
| CAS | 439858-21-6 |
| InChI | InChI=1/C17H19ClN2/c18-16-8-6-15(7-9-16)17(14-4-2-1-3-5-14)20-12-10-19-11-13-20/h1-9,17,19H,10-13H2/t17-/m0/s1 |
(S)-1-(p-Chlorobenzhydryl)piperazine - Physico-chemical Properties
| Molecular Formula | C17H19ClN2 |
| Molar Mass | 286.8 |
| Density | 1.158±0.06 g/cm3(Predicted) |
| Boling Point | 409.1±0.0 °C(Predicted) |
| Flash Point | 193.3°C |
| Vapor Presure | 6.66E-07mmHg at 25°C |
| pKa | 8.99±0.10(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| Refractive Index | 1.592 |
(S)-1-(p-Chlorobenzhydryl)piperazine - Introduction
1-[(S)-(4-chlorohenyl)(phenyl)methyl]piperazine is an organic compound with the chemical formula C19H20ClN and a molecular weight of 307.82g/mol. The compound is a white solid, soluble in ethanol and dimethylformamide at room temperature, almost insoluble in water.
The compound is mainly used in the field of medicine and has antihistamine and antipsychotic activities. It is widely used as a catalyst in the synthesis and preparation of antihistamine drugs. In addition, it is used as a reagent and tool for studying neurotransmission processes.
There are two main methods for preparing 1-[(S)-(4-chlorophenyl)(phenyl)methyl]piperazine. One is generated by the reaction of p-benzylbromide with 4-chloroaniline and piperazine, and the other is synthesized by the reaction of piperazine with (S)-1-((4-chlorophenyl) benzyl) alcohol.
Pay attention to safety when using this compound. It is a potential eye irritant and skin irritant, so appropriate personal protective measures should be taken when handling, such as wearing protective glasses and gloves. In addition, the compound should be stored and handled away from ignition sources and oxidants to avoid the risk of fire and explosion. If there is any misuse or contact, should be timely medical treatment.
The compound is mainly used in the field of medicine and has antihistamine and antipsychotic activities. It is widely used as a catalyst in the synthesis and preparation of antihistamine drugs. In addition, it is used as a reagent and tool for studying neurotransmission processes.
There are two main methods for preparing 1-[(S)-(4-chlorophenyl)(phenyl)methyl]piperazine. One is generated by the reaction of p-benzylbromide with 4-chloroaniline and piperazine, and the other is synthesized by the reaction of piperazine with (S)-1-((4-chlorophenyl) benzyl) alcohol.
Pay attention to safety when using this compound. It is a potential eye irritant and skin irritant, so appropriate personal protective measures should be taken when handling, such as wearing protective glasses and gloves. In addition, the compound should be stored and handled away from ignition sources and oxidants to avoid the risk of fire and explosion. If there is any misuse or contact, should be timely medical treatment.
Last Update：2024-04-09 20:52:54
