(S)-1-BOC-2-AZETIDINEMETHANOL

(S)-1-BOC-2-AZETIDINEMETHANOL - Names and Identifiers

Name	(S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL
Synonyms	(S)-1-(Tert-Butoxycarbon (S)-1-BOC-2-AZETIDINEMETHANOL (S)-N-TERT-BUTOXYCARBONYL-2-AZETIDINYLMETHANOL (S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHAOL (S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL (S)-N-TERT-BUTYLOXYCARBONYL-2-AZETIDINYLMETHANOL (S)-tert-butyl 2-(hydroxymethyl)azetidine-1-carboxylate TERT-BUTYL (2S)-2-(HYDROXYMETHYL)AZETIDINE-1-CARBOXYLATE tert-butyl (2R)-2-(hydroxymethyl)azetidine-1-carboxylate (S)-2-Hydroxymethyl-azetidine-1-carboxylic acid tert-butyl ester
CAS	161511-85-9
InChI	InChI=1/C9H17NO3/c1-9(2,3)13-8(12)10-5-4-7(10)6-11/h7,11H,4-6H2,1-3H3/t7-/m1/s1

(S)-1-BOC-2-AZETIDINEMETHANOL - Physico-chemical Properties

Molecular Formula	C9H17NO3
Molar Mass	187.24
Density	1.05
Boling Point	270.3±13.0 °C(Predicted)
Flash Point	117.303°C
Vapor Presure	0.001mmHg at 25°C
pKa	14.77±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	-74 ° (C=1, MeOH)
MDL	MFCD03093620

(S)-1-BOC-2-AZETIDINEMETHANOL - Risk and Safety

Hazard Symbols	T - Toxic
Risk Codes	25 - Toxic if swallowed
Safety Description	45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN2811

(S)-1-BOC-2-AZETIDINEMETHANOL - Reference Information

application

(S)-1-BOC-2-azetane methanol can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Preparation

Using 2-pyrrolidone as raw material, it is treated with dimethyl sulfate and triethyl oxyfluoroborate respectively to obtain 2-methoxypyrroline and 2-ethoxy-1-pyrroline, the product and the same amount of N-bromosuccinimide (NBS) were refluxed in carbon tetrachloride solvent to obtain 3-bromo-2-alkoxy -1-pyrroline, and the yield of this step could reach 45 ~ 50%. The brominated product is prone to ring-opening reaction to generate γ-amino-bromobutyric acid under dilute hydrochloric acid treatment, and after recrystallization and purification, it is added to the hot alkali solution to react to obtain L-azacyclobutane -2-carboxylic acid.

Last Update：2024-04-09 20:45:29